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    Arp6 Actin-related protein 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arp6provided by FlyBase
    Official Full Name
    Actin-related protein 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0011741
    Locus tag
    Dmel_CG11678
    See related
    AllianceGenome:FB:FBgn0011741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Acrp; actr13E; Actr13E; ARP; ARP(13E); Arp13E; ARP13E; arp4; Arp4; CG11678; dArp6; Dmel\CG11678
    Summary
    Predicted to enable nucleosome binding activity. Involved in transcription initiation-coupled chromatin remodeling. Located in chromatin and nucleus. Is expressed in organism. Orthologous to human ACTR6 (actin related protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Arp6 in Genome Data Viewer
    Location:
    13E12-13E12; 1-51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15735774..15737120, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15629807..15631153, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Magnetic receptor Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin. Frankel S, et al. J Cell Sci, 1997 Sep. PMID 9378752
    2. Novel actin-related proteins in vertebrates: similarities of structure and expression pattern to Arp6 localized on Drosophila heterochromatin. Kato M, et al. Gene, 2001 May 2. PMID 11368909
    3. Identification of a divergent actin-related protein in Drosophila. Frankel S, et al. J Mol Biol, 1994 Jan 28. PMID 8308899
    4. Actin' like actin? Mullins RD, et al. Trends Cell Biol, 1996 Jun. PMID 15157457
    5. Actin-related protein 6 facilitates proneural protein-induced gene activation for rapid neural differentiation. Hsiao YL, et al. Development, 2023 Mar 1. PMID 36897355

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in heterochromatin organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Swr1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin-related protein 6
    Names
    Actin-related protein 13E
    Arp6-PA
    CG11678-PA
    actin-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15735774..15737120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078610.3 → NP_511165.1  Actin-related protein 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45890, Q9VXQ9
      Related
      FBpp0073983
      Conserved Domains (2) summary
      smart00268
      Location:3 → 398
      ACTIN; Actin
      COG5277
      Location:6 → 391
      COG5277; Actin-related protein [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45890.1 P45890

    Gene LinkOut

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