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    Caf1-180 Chromatin assembly factor 1, p180 subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31801, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Caf1-180provided by FlyBase
    Official Full Name
    Chromatin assembly factor 1, p180 subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030054
    Locus tag
    Dmel_CG12109
    See related
    AllianceGenome:FB:FBgn0030054
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAF-1 p180; Caf-180; Caf1; caf1-180; CAF1-180; CAF1-p180; CAF1p180; CG12109; dCAF-1-180; dCAF-1-p180; Dmel\CG12109; NURF; p180; P180
    Summary
    Predicted to contribute to histone binding activity. Involved in several processes, including DNA metabolic process; nucleosome assembly; and response to gamma radiation. Located in nucleus. Part of CAF-1 complex. Is expressed in organism. Human ortholog(s) of this gene implicated in colon cancer; high grade glioma; neuroblastoma; and systemic lupus erythematosus. Orthologous to human CHAF1A (chromatin assembly factor 1 subunit A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Caf1-180 in Genome Data Viewer
    Location:
    7F8-7F8; 1-23 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8602137..8606304, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8496170..8500337, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein Neighboring gene ocelliless Neighboring gene rubicon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Tyler JK, et al. Mol Cell Biol, 1996 Nov. PMID 8887645, Free PMC Article
    2. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. Tyler JK, et al. Mol Cell Biol, 2001 Oct. PMID 11533245, Free PMC Article
    3. Maintenance of Heterochromatin by the Large Subunit of the CAF-1 Replication-Coupled Histone Chaperone Requires Its Interaction with HP1a Through a Conserved Motif. Roelens B, et al. Genetics, 2017 Jan. PMID 27838630, Free PMC Article
    4. ASF1 is required to load histones on the HIRA complex in preparation of paternal chromatin assembly at fertilization. Horard B, et al. Epigenetics Chromatin, 2018 May 11. PMID 29751847, Free PMC Article
    5. Epigenetic Regulation of Notch Signaling During Drosophila Development. Wei C, et al. Adv Exp Med Biol, 2020. PMID 32060871

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
      Title: Inhibition of Notch signaling by the p105 and p180 subunits of Drosophila chromatin assembly factor 1 is required for follicle cell proliferation.
    2. In the absence of P180, germline stem cells still harbor stem cell properties but concomitantly express markers of differentiation. In addition, P180-depleted germ cells exhibit elevated levels of DNA damage and de-repression of the transposable I element. These DNA damages activate p53- and Chk2-dependent checkpoints pathways, leading to cell death and female sterility.
      Title: The replicative histone chaperone CAF1 is essential for the maintenance of identity and genome integrity in adult stem cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to histone binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to gamma radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CAF-1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chromatin assembly factor 1, p180 subunit
    Names
    CAF-1 large subunit
    CAF1 large subunit
    CG12109-PB
    Caf1-180-PB
    large subunit of CAF-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8602137..8606304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132267.5 → NP_572495.1  chromatin assembly factor 1, p180 subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3D1
      Related
      FBpp0071172
      Conserved Domains (4) summary
      pfam12253
      Location:770 → 814
      CAF1A; Chromatin assembly factor 1 subunit A
      pfam15539
      Location:947 → 1127
      CAF1-p150_C2; CAF1 complex subunit p150, region binding to CAF1-p60 at C-term
      cd16269
      Location:573 → 584
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:491 → 599
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SWV8 Q8SWV8
    Q8T9G1 Q8T9G1
    Q9W3D1 Q9W3D1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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