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    Upf3 Upf3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37792, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Upf3provided by FlyBase
    Official Full Name
    Upf3provided by FlyBase
    Primary source
    FLYBASE:FBgn0034923
    Locus tag
    Dmel_CG11184
    See related
    AllianceGenome:FB:FBgn0034923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11184; Dmel\CG11184; dUPF3; upf3; UPF3
    Summary
    Predicted to enable mRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be active in cytoplasm and nucleolus. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability 14. Orthologous to human UPF3A (UPF3A regulator of nonsense mediated mRNA decay) and UPF3B (UPF3B regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Upf3 in Genome Data Viewer
    Location:
    60A8-60A9; 2-105 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23893066..23894987, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19780589..19782510, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Putative homeodomain protein Neighboring gene uncharacterized protein Neighboring gene Decapping protein 1 Neighboring gene DNA ligase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lost PHDs of trr

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tau-induced deficits in nonsense-mediated mRNA decay contribute to neurodegeneration. Zuniga G, et al. Alzheimers Dement, 2023 Feb. PMID 35416419, Free PMC Article
    2. Premature termination codon readthrough in Drosophila varies in a developmental and tissue-specific manner. Chen Y, et al. Sci Rep, 2020 May 22. PMID 32444687, Free PMC Article
    3. Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity. Xu W, et al. Brain, 2019 May 1. PMID 30938419, Free PMC Article
    4. HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis. Xu F, et al. Development, 2024 Jul 15. PMID 38881530
    5. The RNA helicase UPF1 associates with mRNAs co-transcriptionally and is required for the release of mRNAs from gene loci. Singh AK, et al. Elife, 2019 Mar 25. PMID 30907728, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in miRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Upf3
    Names
    CG11184-PB
    CG11184-PD
    Upf3-PB
    Upf3-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23893066..23894987 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166629.2 → NP_726375.1  Upf3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726375.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN82, Q9W1H3
      Related
      FBpp0072130
      Conserved Domains (1) summary
      pfam03467
      Location:27 → 186
      Smg4_UPF3; Smg-4/UPF3 family

    2. NM_138000.3 → NP_611844.3  Upf3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611844.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN82, Q9W1H3
      Conserved Domains (1) summary
      pfam03467
      Location:27 → 186
      Smg4_UPF3; Smg-4/UPF3 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T994 Q8T994
    Q9W1H3 Q9W1H3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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