Dcr-1 Dicer-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dcr-1provided by FlyBase
Official Full Name: Dicer-1provided by FlyBase
Primary source: FLYBASE:FBgn0039016
Locus tag: Dmel_CG4792
See related: AllianceGenome:FB:FBgn0039016
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cg4792; CG4792; Dcr; dcr 1; dcr-1; DCR-1; dcr1; Dcr1; DCR1; dicer; Dicer; DICER; dicer-1; DICER-1; dicer1; Dicer1; dmDcr1; Dmel\CG4792
Summary: Enables pre-miRNA binding activity; ribonuclease III activity; and single-stranded RNA binding activity. Involved in several processes, including dsRNA transport; germ cell development; and regulatory ncRNA-mediated gene silencing. Located in cytosol and nucleus. Part of RISC-loading complex. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Orthologous to human DICER1 (dicer 1, ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94C4-94C4; 3-76 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22734007..22741091, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18559729..18566813, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila.
Title: FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila.
Loqs may have roles in assisting the de novo emergence of miRNA genes by facilitating dicing of suboptimal hairpin substrates.
Title: The Drosophila Dicer-1 Partner Loquacious Enhances miRNA Processing from Hairpins with Unstable Structures at the Dicing Site.
in both Dicer-1 and bantam depleted genetic backgrounds, Dacapo, an inhibitor of cyclin E-Cdk complex, was found to have elevated expression.
Title: Dicer-1 regulates proliferative potential of Drosophila larval neural stem cells through bantam miRNA based down-regulation of the G1/S inhibitor Dacapo.
[review] Dicer-1 lacks a functional DExD/H helicase domain and is responsible for processing hairpin-structured pre-microRNAs.
Title: Dicer's role as an antiviral: still an enigma.
Alternative splicing of the loquacious (loqs)mRNA generates three distinct Dicer partner proteins.
Title: Dicer partner proteins tune the length of mature miRNAs in flies and mammals.
These results reveal a novel interaction between Flock house virus B2 protein and Dicer that leads to suppression of siRNA biogenesis.
Title: Suppression of RNA silencing by Flock house virus B2 protein is mediated through its interaction with the PAZ domain of Dicer.
Dcr-1 and Dap are required for nutrition-dependent cell cycle regulation in germline stem cells (GSCs) and reduction of dap partially rescues the cell cycle defect of Insulin receptor-deficient GSCs
Title: Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells.
r2d2(1) mutants have reduced viability and defective female fertility that stems from abnormal follicle cell function, and Dicer-1 impacts this process
Title: Drosophila R2D2 mediates follicle formation in somatic tissues through interactions with Dicer-1.
Dcr-1 is critical for assembly of microRNA as shown in dcr-1 knockout egg extract
Title: Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes.
Both domains of Loqs-PB are required for efficient miRNA production by enhancing the affinity of Dcr-1 for pre-miRNA.
Title: Functional anatomy of the Drosophila microRNA-generating enzyme.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease III activity	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RISC complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in RNA processing	IEA Inferred from Electronic Annotation more info
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived female germ-line cyst formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germarium-derived oocyte fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in pre-miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment polarity determination	IGI Inferred from Genetic Interaction more info	PubMed
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in siRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of RISC complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RISC-loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC-loading complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC-loading complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RISC-loading complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Dicer-1

Names: CG4792-PA; DICER1; Dcr-1-PA; dicer; dicer 1

NP_524453.1

EC 3.1.21.1

EC 3.1.26.-

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22734007..22741091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079729.3 → NP_524453.1 Dicer-1 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524453.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q961S7, Q9VCU9

UniProtKB/TrEMBL

A0A515MFY5, Q27IU9

Related

FBpp0083717

Conserved Domains (7) summary

cd00593
Location:2008 → 2172

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:1091 → 1212

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:240 → 344

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cl38915
Location:490 → 614

DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases

cd10843
Location:2177 → 2240

DSRM_DICER; double-stranded RNA binding motif of endoribonuclease Dicer and similar proteins

pfam03368
Location:825 → 916

Dicer_dimer; Dicer dimerization domain

cl28899
Location:15 → 208

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q27IU2		Q27IU2
Q27IU3		Q27IU3
Q27IU4		Q27IU4
Q27IU5		Q27IU5
Q27IU6		Q27IU6
Q27IU7		Q27IU7
Q27IU8		Q27IU8
Q27IU9		Q27IU9
Q9VCU9.1		Q9VCU9