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    XNP XNP [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43080, updated on 9-Dec-2024

    Summary

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    Official Symbol
    XNPprovided by FlyBase
    Official Full Name
    XNPprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039338
    Locus tag
    Dmel_CG4548
    See related
    AllianceGenome:FB:FBgn0039338
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ATR-X/XNP; atrx; ATRX; CG4548; DATR-X; datrx; dATRX; DATRX; Dmel\CG4548; dXNP; EP(3)0635; EP635; xnp; Xnp; xnp/atr-x; XNP/dATRX
    Summary
    Enables ATP hydrolysis activity; ATP-dependent chromatin remodeler activity; and DNA translocase activity. Involved in several processes, including neurogenesis; pericentric heterochromatin formation; and regulation of JNK cascade. Located in germinal vesicle. Colocalizes with beta-heterochromatin. Is expressed in several structures, including antennal anlage; antennal primordium; ganglia; germline cell; and head epidermis primordium. Human ortholog(s) of this gene implicated in X-linked mental retardation-hypotonic facies syndrome-1; alpha thalassemia-X-linked intellectual disability syndrome; alpha-thalassemia myelodysplasia syndrome; high grade glioma; and lung small cell carcinoma. Orthologous to human ATRX (ATRX chromatin remodeler). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See XNP in Genome Data Viewer
    Location:
    96E1-96E2; 3-88 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25477868..25482834, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21303590..21308556, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar protein sorting 33B Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glyceronephosphate O-acyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glial ensheathment of the somatodendritic compartment regulates sensory neuron structure and activity. Yadav S, et al. Proc Natl Acad Sci U S A, 2019 Mar 12. PMID 30804200, Free PMC Article
    2. Characterization of the Drosophila group ortholog to the amino-terminus of the alpha-thalassemia and mental retardation X-Linked (ATRX) vertebrate protein. López-Falcón B, et al. PLoS One, 2014. PMID 25437195, Free PMC Article
    3. ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease. Lee J, et al. Cell Death Differ, 2012 Jul. PMID 22240898, Free PMC Article
    4. Protein complex of Drosophila ATRX/XNP and HP1a is required for the formation of pericentric beta-heterochromatin in vivo. Emelyanov AV, et al. J Biol Chem, 2010 May 14. PMID 20154359, Free PMC Article
    5. dAdd1 and dXNP prevent genome instability by maintaining HP1a localization at Drosophila telomeres. Chavez J, et al. Chromosoma, 2017 Dec. PMID 28688038

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA translocase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA translocase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with beta-heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in germinal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    XNP
    Names
    CG4548-PA
    CG4548-PB
    CG4548-PC
    CG4548-PD
    XNP-PA
    XNP-PB
    XNP-PC
    XNP-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25477868..25482834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170228.3 → NP_733107.1  XNP, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733107.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3E4, Q9GQN5, Q9VBQ8
      Related
      FBpp0084212
      Conserved Domains (4) summary
      cd00046
      Location:483 → 646
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:458 → 779
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:913 → 1035
      Helicase_C; Helicase conserved C-terminal domain
      pfam08070
      Location:258 → 335
      DTHCT; DTHCT (NUC029) region

    2. NM_001300598.1 → NP_001287527.1  XNP, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287527.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR3
      Conserved Domains (4) summary
      cd00046
      Location:218 → 381
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:193 → 514
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:648 → 770
      Helicase_C; Helicase conserved C-terminal domain
      pfam14797
      Location:3 → 84
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex

    3. NM_143141.4 → NP_651398.1  XNP, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651398.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3E4, Q9GQN5, Q9VBQ8
      Related
      FBpp0084213
      Conserved Domains (4) summary
      cd00046
      Location:483 → 646
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:458 → 779
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:913 → 1035
      Helicase_C; Helicase conserved C-terminal domain
      pfam08070
      Location:258 → 335
      DTHCT; DTHCT (NUC029) region

    4. NM_001300599.1 → NP_001287528.1  XNP, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287528.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LHR3
      Conserved Domains (4) summary
      cd00046
      Location:218 → 381
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:193 → 514
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:648 → 770
      Helicase_C; Helicase conserved C-terminal domain
      pfam14797
      Location:3 → 84
      SEEEED; Serine-rich region of AP3B1, clathrin-adaptor complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHR3 A0A0B4LHR3
    Q8T9C9 Q8T9C9
    Q9GQN5.2 Q9GQN5

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