U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    wol wollknaeuel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34134, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    wolprovided by FlyBase
    Official Full Name
    wollknaeuelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261020
    Locus tag
    Dmel_CG7870
    See related
    AllianceGenome:FB:FBgn0261020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alg5; Alg5; ALG5; CG7870; dAlg5; Dmel\CG7870; Wol
    Summary
    Enables dolichyl-phosphate beta-glucosyltransferase activity. Involved in several processes, including gastrulation; protein glycosylation; and septate junction assembly. Located in endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic proventriculus inner layer; gland; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See wol in Genome Data Viewer
    Location:
    29A3-29A3; 2-31 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8301345..8302985, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8301345..8302985, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Bruton tyrosine kinase Neighboring gene transfer RNA:Lysine-TTT 1-1 Neighboring gene long non-coding RNA:CR43752 Neighboring gene Sarcoglycan alpha Neighboring gene Oligosaccharide transferase gamma subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structures and functions of invertebrate glycosylation. Zhu F, et al. Open Biol, 2019 Jan 31. PMID 30958118, Free PMC Article
    2. The Alg5 ortholog Wollknäuel is essential for correct epidermal differentiation during Drosophila late embryogenesis. Shaik KS, et al. Glycobiology, 2011 Jun. PMID 21199819
    3. Wollknauel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase. Haecker A, et al. Development, 2008 May. PMID 18403407
    4. The glucosyltransferase Xiantuan of the endoplasmic reticulum specifically affects E-Cadherin expression and is required for gastrulation movements in Drosophila. Zhang Y, et al. Dev Biol, 2014 Jun 15. PMID 24681004
    5. Expression profiling of Drosophila imaginal discs. Klebes A, et al. Genome Biol, 2002 Jul 24. PMID 12186645, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gastrulation involving germ band extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm migration involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in segment specification HMP PubMed 
    involved_in septate junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    wollknaeuel
    Names
    CG7870-PA
    wol-PA
    wollknauel
    NP_609202.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8301345..8302985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135358.2 → NP_609202.1  wollknaeuel [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609202.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VLQ1
      Related
      FBpp0079234
      Conserved Domains (1) summary
      cd04188
      Location:70 → 290
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VLQ1.1 Q9VLQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous