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    E(spl)m2-BFM Enhancer of split m2, Bearded family member [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43155, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E(spl)m2-BFMprovided by FlyBase
    Official Full Name
    Enhancer of split m2, Bearded family memberprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002592
    Locus tag
    Dmel_CG6104
    See related
    AllianceGenome:FB:FBgn0002592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6104; DmelCG6104; Dmel\CG6104; E(spl); E(spl)m2; E(Spl)m2; HLHm2; m2
    Summary
    Involved in cell fate specification; positive regulation of Notch signaling pathway; and sensory organ development. Is expressed in several structures, including Johnston organ; epithelium; gut section; head epidermis primordium; and imaginal disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See E(spl)m2-BFM in Genome Data Viewer
    Location:
    96F10-96F10; 3-89 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26016514..26017470, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21842236..21843192, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Enhancer of split malpha, Bearded family member Neighboring gene long non-coding RNA:CR45040 Neighboring gene Kazal-type protease inhibitor m1 Neighboring gene long non-coding RNA:CR43643 Neighboring gene long non-coding RNA:CR43644

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effects of methylmercury on Notch signaling during embryonic neural development in Drosophila melanogaster. Engel GL, et al. Toxicol In Vitro, 2012 Apr. PMID 22230562, Free PMC Article
    2. Neural hyperplasia induced by RNA interference with m4/malpha gene activity. Nagel AC, et al. Mech Dev, 2000 Nov. PMID 11044604
    3. Molecular analysis of the neurogenic locus Enhancer of split of Drosophila melanogaster. Knust E, et al. EMBO J, 1987 Dec 20. PMID 16453817, Free PMC Article
    4. A functional analysis of the genes Enhancer of split and HLH-m5 during early neurogenesis in Drosophila melanogaster. Tietze K, et al. Rouxs Arch Dev Biol, 1993 Jan. PMID 28305975
    5. Differential expression of the Enhancer of split genes in the developing Drosophila midgut. Maeder ML, et al. Hereditas, 2009 Feb. PMID 19348652

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables ubiquitin protein ligase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of split m2, bearded family member
    Names
    CG6104-PA
    E(spl) region transcript m2
    E(spl)m2-BFM-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26016514..26017470 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079784.3 → NP_524508.1  enhancer of split m2, bearded family member [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524508.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97177, Q5S3Y0, Q5S3Y1, Q5S3Y3, Q5S456, Q5S480, Q5S4A4, Q5S4B6, Q5S4H6, Q5S4K0
      Related
      FBpp0084354
      Conserved Domains (1) summary
      pfam15952
      Location:1 → 216
      ESM4; Enhancer of split M4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97177.1 O97177

    Gene LinkOut

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