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    MtnB Metallothionein B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42424, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MtnBprovided by FlyBase
    Official Full Name
    Metallothionein Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002869
    Locus tag
    Dmel_CG4312
    See related
    AllianceGenome:FB:FBgn0002869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4312; Dmel\CG4312; DrosMto; MT; MTN; MtnA; mtnb; mtnB; MTNB; Mto; MTO
    Summary
    Enables copper ion binding activity. Involved in cellular detoxification of metal ion and response to metal ion. Is expressed in embryonic/larval posterior midgut and gastric caecum. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MtnB in Genome Data Viewer
    Location:
    92E12-92E13; 3-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20503102..20503746, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16328824..16329468, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44401 Neighboring gene Dicarboxylate carrier 2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 92a Neighboring gene Major Facilitator Superfamily Transporter 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Raman study of in vivo synthesized Zn(II)-metallothionein complexes: structural insight into metal clusters and protein folding. Torreggiani A, et al. Biopolymers, 2008 Dec. PMID 18690663
    2. The ovicidal, larvacidal and adulticidal properties of 5,5'-dimethyl-2,2'-bipyridyl against Drosophila melanogaster. Van Hiel MB, et al. PLoS One, 2012. PMID 23185497, Free PMC Article
    3. Metal-metal interaction mediates the iron induction of Drosophila MtnB. Qiang W, et al. Biochem Biophys Res Commun, 2017 Jun 3. PMID 28435068
    4. Metallothionein Mto gene of Drosophila melanogaster: structure and regulation. Silar P, et al. J Mol Biol, 1990 Sep 20. PMID 1976815
    5. Polyglutamine tracts as modulators of transcriptional activation from yeast to mammals. Atanesyan L, et al. Biol Chem, 2012 Jan. PMID 22628299

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, iron-mediated MtnB induction appears resulting from interrupted homeostasis of other metals such as zinc, which in turns induced MtnB expression. Metal-metal interaction may more widely exist than we expected.
      Title: Metal-metal interaction mediates the iron induction of Drosophila MtnB.
    2. MTO metal binding features were analyzed for comparison with MTN, the paralogous Drosophila metallothionein, and to classify MTO as either zinc- or copper-thionein.
      Title: MTO: the second member of a Drosophila dual copper-thionein system.
    3. the preferential protection against copper and cadmium toxicity by MtnA and MtnB, respectively, are the result of a combination of promoter preference and metal binding
      Title: The four members of the Drosophila metallothionein family exhibit distinct yet overlapping roles in heavy metal homeostasis and detoxification.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of metal ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to metal ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to metal ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    metallothionein B
    Names
    CG4312-PA
    CG4312-PB
    CG4312-PC
    MtnB-PA
    MtnB-PB
    MtnB-PC
    metallothionein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20503102..20503746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300497.1 → NP_001287426.1  metallothionein B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11956, Q1ECC1, Q9VDM2
      UniProtKB/TrEMBL
      A0A0B4LHD1
      Conserved Domains (1) summary
      pfam02067
      Location:1 → 41
      Metallothio_5; Metallothionein family 5

    2. NM_001300496.1 → NP_001287425.1  metallothionein B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287425.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11956, Q1ECC1, Q9VDM2
      UniProtKB/TrEMBL
      A0A0B4LHD1
      Conserved Domains (1) summary
      pfam02067
      Location:1 → 41
      Metallothio_5; Metallothionein family 5

    3. NM_079689.3 → NP_524413.1  metallothionein B, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524413.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11956, Q1ECC1, Q9VDM2
      UniProtKB/TrEMBL
      A0A0B4LHD1
      Related
      FBpp0083298
      Conserved Domains (1) summary
      pfam02067
      Location:1 → 41
      Metallothio_5; Metallothionein family 5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHD1 A0A0B4LHD1
    P11956.1 P11956

    Gene LinkOut

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