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    Psc Posterior sex combs [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36431, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pscprovided by FlyBase
    Official Full Name
    Posterior sex combsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0005624
    Locus tag
    Dmel_CG3886
    See related
    AllianceGenome:FB:FBgn0005624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    49Ea; CG3886; D-Bmi; Dmel\CG3886; dPSC; l(2)49Ea; l(2)Psc; l(2)vr14; psc; PSC; Psc1; Su(z)2-C; Suz2; vr14
    Summary
    Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in anterior/posterior axis specification; regulation of gene expression; and syncytial blastoderm mitotic cell cycle. Located in nucleus. Part of PRC1 complex. Is expressed in several structures, including brain; central nervous system; embryonic/larval salivary gland; imaginal disc; and larval ventral nerve cord. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Psc in Genome Data Viewer
    Location:
    49E6-49E6; 2-67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12965997..12980994, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8853502..8868499, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44339 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A core subunit of Polycomb repressive complex 1 is broadly conserved in function but not primary sequence. Beh LY, et al. Proc Natl Acad Sci U S A, 2012 May 1. PMID 22517748, Free PMC Article
    2. A bridging model for persistence of a polycomb group protein complex through DNA replication in vitro. Lo SM, et al. Mol Cell, 2012 Jun 29. PMID 22749399, Free PMC Article
    3. Chromatin modification by PSC occurs at one PSC per nucleosome and does not require the acidic patch of histone H2A. Lo SM, et al. PLoS One, 2012. PMID 23071745, Free PMC Article
    4. Shaping epigenetic memory via genomic bookmarking. Michieletto D, et al. Nucleic Acids Res, 2018 Jan 9. PMID 29190361, Free PMC Article
    5. Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene. Brunk BP, et al. Nature, 1991 Sep 26. PMID 1833647

    See all (397) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA Binding Reorganizes the Intrinsically Disordered C-Terminal Region of PSC in Drosophila PRC1.
      Title: DNA Binding Reorganizes the Intrinsically Disordered C-Terminal Region of PSC in Drosophila PRC1.
    2. Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
      Title: Polycomb group genes Psc and Su(z)2 maintain somatic stem cell identity and activity in Drosophila.
    3. The Psc-Su(z)2 locus is flanked by insulator elements that may protect neighboring genes from inappropriate silencing.
      Title: Regulation of Polycomb group genes Psc and Su(z)2 in Drosophila melanogaster.
    4. study describes a transcription-independent function for PSC in regulating the destruction of cyclin B; PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis
      Title: Transcription-independent function of Polycomb group protein PSC in cell cycle control.
    5. Posterior sex combs (Psc), which encodes a core Polycomb-repressive complex 1 (PRC1) component, functions redundantly with a similar gene, Suppressor of zeste two [Su(z)2], to restrict follicle stem cell (FSC) self-renewal in the Drosophila ovary
      Title: Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling.
    6. Psc encodes at least two functions, complex formation and the inhibition of remodeling and transcription, which require different regions of the protein.
      Title: Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in syncytial blastoderm mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    posterior sex combs
    Names
    CG3886-PA
    CG3886-PB
    CG3886-PC
    Psc-PA
    Psc-PB
    Psc-PC
    posterior sex comb
    posterior-sex-combs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12965997..12980994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299440.1 → NP_001286369.1  posterior sex combs, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286369.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35820, Q9V6I9
      UniProtKB/TrEMBL
      D0Z760
      Conserved Domains (2) summary
      pfam00097
      Location:263 → 301
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:384 → 465
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    2. NM_079001.3 → NP_523725.2  posterior sex combs, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523725.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35820, Q9V6I9
      UniProtKB/TrEMBL
      D0Z760
      Related
      FBpp0086911
      Conserved Domains (2) summary
      pfam00097
      Location:263 → 301
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:384 → 465
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like

    3. NM_001299439.1 → NP_001286368.1  posterior sex combs, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P35820, Q9V6I9
      UniProtKB/TrEMBL
      D0Z760
      Conserved Domains (2) summary
      pfam00097
      Location:263 → 301
      zf-C3HC4; Zinc finger, C3HC4 type (RING finger)
      pfam16207
      Location:384 → 465
      RAWUL; RAWUL domain RING finger- and WD40-associated ubiquitin-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0Z760 D0Z760
    P35820.2 P35820

    Gene LinkOut

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