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    Chd3 Chd3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chd3provided by FlyBase
    Official Full Name
    Chd3provided by FlyBase
    Primary source
    FLYBASE:FBgn0023395
    Locus tag
    Dmel_CG9594
    See related
    AllianceGenome:FB:FBgn0023395
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9594; CHD-3; chd3; CHD3; dCHD3; DmCHD3; Dmel\CG9594
    Summary
    Enables ATP hydrolysis activity and ATP-dependent chromatin remodeler activity. Involved in nucleosome organization. Located in euchromatin and nucleus. Orthologous to human CHD3 (chromodomain helicase DNA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Chd3 in Genome Data Viewer
    Location:
    76B3-76B3; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19447173..19450238)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19440273..19443338)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45732 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45434 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UNC13B variants associated with partial epilepsy with favourable outcome. Wang J, et al. Brain, 2021 Nov 29. PMID 33876820, Free PMC Article
    2. The Chd family of chromatin remodelers. Marfella CG, et al. Mutat Res, 2007 May 1. PMID 17350655, Free PMC Article
    3. Characterization of the CHD family of proteins. Woodage T, et al. Proc Natl Acad Sci U S A, 1997 Oct 14. PMID 9326634, Free PMC Article
    4. dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription. Murawska M, et al. Mol Cell Biol, 2008 Apr. PMID 18250149, Free PMC Article
    5. Do protein motifs read the histone code? de la Cruz X, et al. Bioessays, 2005 Feb. PMID 15666348

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dCHD3 exists as a monomer
      Title: dCHD3, a novel ATP-dependent chromatin remodeler associated with sites of active transcription.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent chromatin remodeler activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP-dependent chromatin remodeler activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleosome organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuRD complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chd3
    Names
    CG9594-PA
    Chd3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19447173..19450238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140854.3 → NP_649111.1  Chd3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649111.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16102, Q8SYJ8, Q9VVZ3
      UniProtKB/TrEMBL
      M9W9W1
      Related
      FBpp0074766
      Conserved Domains (6) summary
      smart00298
      Location:181 → 233
      CHROMO; Chromatin organization modifier domain
      cd00024
      Location:85 → 147
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00046
      Location:288 → 440
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd15532
      Location:37 → 79
      PHD2_CHD_II; PHD finger 2 found in class II Chromodomain-Helicase-DNA binding (CHD) proteins
      pfam00176
      Location:270 → 561
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:585 → 700
      Helicase_C; Helicase conserved C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16102.3 O16102

    Gene LinkOut

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