Eph Eph receptor tyrosine kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ephprovided by FlyBase
Official Full Name: Eph receptor tyrosine kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0025936
Locus tag: Dmel_CG1511
See related: AllianceGenome:FB:FBgn0025936
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1511; CT3831; dek; Dek; DEK; Dek7; Deph; Dmel\CG1511; Ek7; eph; EPH; lincRNA.923; RPTK Dek7
Summary: Predicted to enable transmembrane-ephrin receptor activity. Involved in melanotic encapsulation of foreign target; mushroom body development; and peripheral nervous system development. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adult head; eye disc posterior to the morphogenetic furrow; larval central nervous system; neuron projection bundle of larval ventral nerve cord; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant nonsyndromic deafness 88; cataract 6 multiple types; central conducting lymphatic anomaly; pancreatic cancer; and prostate cancer. Orthologous to several human genes including EPHA3 (EPH receptor A3); EPHA4 (EPH receptor A4); and EPHA5 (EPH receptor A5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 102D1-102D1; 4-0 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (610684..622470)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (631310..643096)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eph signaling is a novel extrinsic mechanism that regulates both spindle orientation and cell proliferation in the Drosophila optic lobe neuroepithelium.
Title: Eph signaling controls mitotic spindle orientation and cell proliferation in neuroepithelial cells.
Eph and Ephrin, the well-known axon guidance molecules, instruct the dendrodendritic segregation during the discrete olfactory map formation
Title: Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila.
Eph receptors have important functions in shaping compartment boundaries in both vertebrate and insect development.
Title: An RNA interference screen for genes required to shape the anteroposterior compartment boundary in Drosophila identifies the Eph receptor.
we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels
Title: A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels.
role for Drosophila Eph receptor tyrosine kinase (EPH) signaling in the control of photoreceptor axon and cortical axon topography in the developing visual system
Title: Eph receptor tyrosine kinase-mediated formation of a topographic map in the Drosophila visual system.
Eph receptor guides specific axon branches of mushroom body neurons.
Title: Drosophila Eph receptor guides specific axon branches of mushroom body neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 616660-616773 mobile_element_type = transposon:INE-1{}1906
Loc: 619327-619377 mobile_element_type = transposon:INE-1{}1907

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in melanotic encapsulation of foreign target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eph receptor tyrosine kinase

Names: CG1511-PA; CG1511-PB; CG1511-PC; CG1511-PD; CG1511-PE; CG1511-PF; Eph kinase; Eph receptor; Eph-PA; Eph-PB; Eph-PC; Eph-PD; Eph-PE; Eph-PF; Erythropoietin-producing human; drosophila eph; ephrin receptor; ephrin receptors; hepatocellular carcinoma cell line

NP_001162824.1

EC 2.7.10.1

NP_524625.3

EC 2.7.10.1

NP_726588.2

EC 2.7.10.1

NP_726589.2

EC 2.7.10.1

NP_726590.2

EC 2.7.10.1

NP_726591.2

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

610684..622470

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166776.4 → NP_726590.2 Eph receptor tyrosine kinase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726590.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0KIF4, Q9Y1J0

Conserved Domains (7) summary

smart00454
Location:1023 → 1076

SAM; Sterile alpha motif

cd10319
Location:85 → 260

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:536 → 623

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:720 → 986

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam00536
Location:1017 → 1076

SAM_1; SAM domain (Sterile alpha motif)

pfam07714
Location:725 → 983

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:644 → 720

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_079886.5 → NP_524625.3 Eph receptor tyrosine kinase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524625.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9V4E5, Q9Y1J0

Conserved Domains (7) summary

smart00454
Location:1039 → 1092

SAM; Sterile alpha motif

cd10319
Location:85 → 260

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:536 → 623

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:736 → 1002

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam00536
Location:1033 → 1092

SAM_1; SAM domain (Sterile alpha motif)

pfam07714
Location:741 → 999

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:644 → 736

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_166775.4 → NP_726589.2 Eph receptor tyrosine kinase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726589.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0KIF4, Q9Y1J0

Conserved Domains (7) summary

smart00454
Location:1023 → 1076

SAM; Sterile alpha motif

cd10319
Location:85 → 260

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:536 → 623

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:720 → 986

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam00536
Location:1017 → 1076

SAM_1; SAM domain (Sterile alpha motif)

pfam07714
Location:725 → 983

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:644 → 720

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_166777.4 → NP_726591.2 Eph receptor tyrosine kinase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726591.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8IMC2, Q9Y1J0

Conserved Domains (7) summary

smart00454
Location:990 → 1043

SAM; Sterile alpha motif

cd10319
Location:52 → 227

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:503 → 590

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:687 → 953

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam00536
Location:984 → 1043

SAM_1; SAM domain (Sterile alpha motif)

pfam07714
Location:692 → 950

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:611 → 687

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_001169353.2 → NP_001162824.1 Eph receptor tyrosine kinase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162824.1

Status: REVIEWED

UniProtKB/TrEMBL

D1YSF9, O96435

Conserved Domains (5) summary

cd10319
Location:52 → 227

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:503 → 590

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:703 → 969

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam07714
Location:708 → 966

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:611 → 703

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
NM_166774.3 → NP_726588.2 Eph receptor tyrosine kinase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726588.2

Status: REVIEWED

UniProtKB/TrEMBL

Q59DQ4, Q9Y1J0

Conserved Domains (5) summary

cd10319
Location:85 → 260

EphR_LBD; Ligand Binding Domain of Ephrin Receptors

cd00063
Location:536 → 623

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05033
Location:736 → 1002

PTKc_EphR; Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases

pfam07714
Location:741 → 999

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:644 → 736

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
D1YSF9		D1YSF9
O96435		O96435
Q0KIF4		Q0KIF4
Q59DQ4		Q59DQ4
Q5BIC7		Q5BIC7
Q8IMC2		Q8IMC2
Q8MT37		Q8MT37
Q9V4E5		Q9V4E5
Q9XZL6		Q9XZL6
Q9Y1J0		Q9Y1J0