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    Hey Hairy/E(spl)-related with YRPW motif [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Heyprovided by FlyBase
    Official Full Name
    Hairy/E(spl)-related with YRPW motifprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027788
    Locus tag
    Dmel_CG11194
    See related
    AllianceGenome:FB:FBgn0027788
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bHLHe44; CG11194; d-hey; dHey; Dmel\CG11194; hesr-1; Hesr-1; hey; HEY
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron fate determination. Located in nucleus. Is expressed in several structures, including embryonic thoracic segment; ganglia; larval CNS neuron; larval optic anlage; and presumptive embryonic/larval system. Orthologous to several human genes including HEY1 (hes related family bHLH transcription factor with YRPW motif 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hey in Genome Data Viewer
    Location:
    44A2-44A2; 2-58 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7995438..7998278, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3882943..3885783, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44272 Neighboring gene Dicarboxylate carrier 3 Neighboring gene uncharacterized protein Neighboring gene Ornithine decarboxylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS. Mark B, et al. Elife, 2021 May 11. PMID 33973523, Free PMC Article
    2. Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split. Kokubo H, et al. Biochem Biophys Res Commun, 1999 Jul 5. PMID 10403790
    3. Expression of Hey marks a subset of enteroendocrine cells in the Drosophila embryonic and larval midgut. Skafida E, et al. Int J Dev Biol, 2022. PMID 34881798
    4. hnRNP K: one protein multiple processes. Bomsztyk K, et al. Bioessays, 2004 Jun. PMID 15170860
    5. Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types. Xu C, et al. Elife, 2024 Jan 9. PMID 38193901, Free PMC Article

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Hairy/E(spl)-related with YRPW motif
    Names
    CG11194-PA
    Hairy/E(spl)
    Hairy/E(spl) related with YRPW motif
    Hairy/E(spl)-related
    Hey-PA
    hairy and enhancer of split related protein
    hairy and enhancer of split related-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7995438..7998278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078933.3 → NP_523657.1  Hairy/E(spl)-related with YRPW motif [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q058S4, Q7KM13
      Related
      FBpp0087945
      Conserved Domains (2) summary
      smart00511
      Location:172 → 218
      ORANGE; Orange domain
      cd00083
      Location:100 → 156
      HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KM13.1 Q7KM13

    Gene LinkOut

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