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    CG12206 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31316, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12206provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029662
    Locus tag
    Dmel_CG12206
    See related
    AllianceGenome:FB:FBgn0029662
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12206
    Summary
    Predicted to be involved in sensory perception of sound. Is expressed in several structures, including embryonic dorsal epidermis; embryonic head epidermis; embryonic ventral epidermis; embryonic/larval posterior spiracle; and embryonic/larval tracheal section. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Orthologous to human GRXCR1 (glutaredoxin and cysteine rich domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12206 in Genome Data Viewer
    Location:
    3D4-3D4; 1-3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3465737..3474524, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3359770..3368557, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44999 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
    2. Gbb glutathionylation promotes its proteasome-mediated degradation to inhibit synapse growth. Hossain MS, et al. J Cell Biol, 2023 Sep 4. PMID 37389657, Free PMC Article
    3. dusky-like is required to maintain the integrity and planar cell polarity of hairs during the development of the Drosophila wing. Adler PN, et al. Dev Biol, 2013 Jul 1. PMID 23623898, Free PMC Article
    4. Gene expression profiling of Drosophila tracheal fusion cells. Chandran RR, et al. Gene Expr Patterns, 2014 Jul. PMID 24928808
    5. A Drosophila screen identifies a role for histone methylation in ER stress preconditioning. Owings KG, et al. G3 (Bethesda), 2024 Feb 7. PMID 38098286, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12206-PA
    CG12206-PB
    CG12206-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3465737..3474524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130704.2 → NP_570060.1  uncharacterized protein Dmel_CG12206, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4S1
      Related
      FBpp0070503
      Conserved Domains (1) summary
      cd03031
      Location:434 → 579
      GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...

    2. NM_166973.2 → NP_726865.1  uncharacterized protein Dmel_CG12206, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4S1
      Related
      FBpp0070504
      Conserved Domains (1) summary
      cd03031
      Location:434 → 579
      GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...

    3. NM_166974.1 → NP_726866.1  uncharacterized protein Dmel_CG12206, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W4S1
      Related
      FBpp0070505, FBtr0070529
      Conserved Domains (1) summary
      cd03031
      Location:434 → 579
      GRX_GRX_like; Glutaredoxin (GRX) family, GRX-like domain containing protein subfamily; composed of uncharacterized eukaryotic proteins containing a GRX-like domain having only one conserved cysteine, aligning to the C-terminal cysteine of the CXXC motif of GRXs. This ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4S1.2 Q9W4S1

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