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    Irk3 Inwardly rectifying potassium channel 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35131, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Irk3provided by FlyBase
    Official Full Name
    Inwardly rectifying potassium channel 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0032706
    Locus tag
    Dmel_CG10369
    See related
    AllianceGenome:FB:FBgn0032706
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10369; dIRK-3; dKirIII; Dmel\CG10369; irk3
    Summary
    Predicted to enable inward rectifier potassium channel activity. Involved in wing disc development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult Malpighian tubule principal cell; adult head; epithelial tube; and female germline cell. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Irk3 in Genome Data Viewer
    Location:
    37A1-37A1; 2-54 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18711071..18713748, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18711071..18713748, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Jwa Neighboring gene Fas-associated factor 2 Neighboring gene Grip71 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44768 Neighboring gene long non-coding RNA:CR44769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inwardly rectifying potassium channels in Drosophila. Luan Z, et al. Sheng Li Xue Bao, 2012 Oct 25. PMID 23090492
    2. Two inwardly rectifying potassium channels, Irk1 and Irk2, play redundant roles in Drosophila renal tubule function. Wu Y, et al. Am J Physiol Regul Integr Comp Physiol, 2015 Oct. PMID 26224687, Free PMC Article
    3. Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function. Evans JM, et al. J Exp Biol, 2005 Oct. PMID 16169954
    4. Inwardly rectifying K+ (Kir) channels in Drosophila. A crucial role of cellular milieu factors Kir channel function. Döring F, et al. J Biol Chem, 2002 Jul 12. PMID 11964404
    5. Insulin signaling, lifespan and stress resistance are modulated by metabotropic GABA receptors on insulin producing cells in the brain of Drosophila. Enell LE, et al. PLoS One, 2010 Dec 30. PMID 21209905, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inward rectifier potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of membrane potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inwardly rectifying potassium channel 3
    Names
    CG10369-PA
    CG10369-PC
    CG10369-PD
    Irk3-PA
    Irk3-PC
    Irk3-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      18711071..18713748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136059.4 → NP_609903.2  inwardly rectifying potassium channel 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609903.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQ80, Q9VJ56
      Conserved Domains (1) summary
      cl21560
      Location:115 → 428
      Ion_trans_2; Ion channel

    2. NM_001144363.2 → NP_001137835.2  inwardly rectifying potassium channel 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137835.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZX2
      Conserved Domains (2) summary
      pfam01007
      Location:119 → 265
      IRK; Inward rectifier potassium channel
      pfam17655
      Location:272 → 432
      IRK_C; Inward rectifier potassium channel C-terminal domain

    3. NM_001299129.1 → NP_001286058.1  inwardly rectifying potassium channel 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286058.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAW9
      Conserved Domains (1) summary
      cl21560
      Location:115 → 144
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7YZX2 B7YZX2
    Q9VJ56 Q9VJ56
    X2JAW9 X2JAW9

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