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    hrg hiiragi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49636, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hrgprovided by FlyBase
    Official Full Name
    hiiragiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015949
    Locus tag
    Dmel_CG9854
    See related
    AllianceGenome:FB:FBgn0015949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9854; dHrg; Dmel\CG9854; Hiiragi; l(2)07619; l(2)k07619; Pap; PAP
    Summary
    Enables poly(A) RNA polymerase activity. Involved in cytosolic mRNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; epithelial cell; epithelium; ganglia; and gonad. Orthologous to several human genes including PAPOLA (poly(A) polymerase alpha) and PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See hrg in Genome Data Viewer
    Location:
    56E1-56E1; 2-90 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19663919..19669832, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15551424..15557337, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44504 Neighboring gene mir-309 stem loop Neighboring gene uncharacterized protein Neighboring gene Kip1 ubiquitination-promoting complex subunit 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. Murata T, et al. Dev Biol, 2001 May 1. PMID 11319863
    2. Modulating the bicoid gradient in space and time. Cai X, et al. Hereditas, 2021 Aug 17. PMID 34404481, Free PMC Article
    3. Maheshvara, a Conserved RNA Helicase, Regulates Notch Signaling in Drosophila melanogaster. Maurya B, et al. Adv Exp Med Biol, 2020. PMID 32072499
    4. The Drosophila PNG kinase complex regulates the translation of cyclin B. Vardy L, et al. Dev Cell, 2007 Jan. PMID 17199048
    5. Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila. Juge F, et al. EMBO J, 2002 Dec 2. PMID 12456666, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
      Title: Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(A) RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytosolic mRNA polyadenylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hiiragi
    Names
    CG9854-PA
    CG9854-PB
    CG9854-PC
    CG9854-PD
    Poly(A) polymerase
    hrg-PA
    hrg-PB
    hrg-PC
    hrg-PD
    poly (A) polymerase
    NP_001036562.1
    NP_001261097.1
    NP_536790.1
    NP_725919.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19663919..19669832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080529.4 → NP_536790.1  hiiragi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_536790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ09, Q9N6D7
      Related
      FBpp0085678
      Conserved Domains (3) summary
      PTZ00418
      Location:28 → 600
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:374 → 534
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:29 → 371
      PAP_central; Poly(A) polymerase central domain

    2. NM_001274168.2 → NP_001261097.1  hiiragi, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261097.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG96
      Conserved Domains (3) summary
      PTZ00418
      Location:28 → 600
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:374 → 534
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:29 → 371
      PAP_central; Poly(A) polymerase central domain

    3. NM_166372.3 → NP_725919.1  hiiragi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ09, Q9N6D7
      Related
      FBpp0085679
      Conserved Domains (3) summary
      PTZ00418
      Location:28 → 600
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:374 → 534
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:29 → 371
      PAP_central; Poly(A) polymerase central domain

    4. NM_001043097.3 → NP_001036562.1  hiiragi, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ09, Q9N6D7
      Conserved Domains (3) summary
      PTZ00418
      Location:28 → 600
      PTZ00418; Poly(A) polymerase; Provisional
      pfam04926
      Location:374 → 534
      PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
      pfam04928
      Location:29 → 371
      PAP_central; Poly(A) polymerase central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KG96 A0A0B4KG96
    Q8MZ09 Q8MZ09
    Q9N6D7 Q9N6D7
    Q9NDU1 Q9NDU1
    Q9NDU2 Q9NDU2

    Gene LinkOut

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