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    Cht8 Chitinase 8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37390, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cht8provided by FlyBase
    Official Full Name
    Chitinase 8provided by FlyBase
    Primary source
    FLYBASE:FBgn0034580
    Locus tag
    Dmel_CG9357
    See related
    AllianceGenome:FB:FBgn0034580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9357; Cht; cht8; DmCht8; Dmel\CG9357
    Summary
    Predicted to enable chitin binding activity and chitinase activity. Involved in ecdysis, chitin-based cuticle. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cht8 in Genome Data Viewer
    Location:
    57B16-57B16; 2-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21061646..21063212)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16949151..16950717)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene capping protein alpha Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 12 Neighboring gene Chitinase 4 Neighboring gene antisense RNA:CR44703 Neighboring gene Chitinase 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of mind the gap in the organization of the tracheal apical extracellular matrix in Drosophila and Nilaparvata lugens. Yue XZ, et al. Insect Sci, 2020 Aug. PMID 31240817
    2. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
    3. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175
    4. Chitinase family GH18: evolutionary insights from the genomic history of a diverse protein family. Funkhouser JD, et al. BMC Evol Biol, 2007 Jun 26. PMID 17594485, Free PMC Article
    5. Manual curation and phylogenetic analysis of chitinase family genes in the Asian citrus psyllid, Diaphorina citri. Shippy TD, et al. GigaByte, 2022. PMID 36824529, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    chitinase 8
    Names
    CG9357-PA
    Cht8-PA
    NP_611542.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21061646..21063212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137698.1 → NP_611542.2  chitinase 8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611542.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2M7
      Related
      FBpp0071463, FBtr0071534
      Conserved Domains (3) summary
      cd02872
      Location:31 → 400
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:31 → 379
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:424 → 476
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MSI4 Q8MSI4
    Q9W2M7 Q9W2M7

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