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    Obsc Obscurin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346201, updated on 9-Dec-2024

    Summary

    Official Symbol
    Obscprovided by FlyBase
    Official Full Name
    Obscurinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053519
    Locus tag
    Dmel_CG33519
    See related
    AllianceGenome:FB:FBgn0053519
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:HL01080; CG18019; CG18020; CG18021; CG30171; CG30175; CG33519; CG3901; CT12925; CT40322; CT40326; Dmel\CG33519; dmObsc; obs; unc-89; Unc-89; UNC-89
    Summary
    Enables ATP binding activity; protein kinase binding activity; and tropomyosin binding activity. Involved in adult somatic muscle development; protein localization to M-band; and sarcomere organization. Located in M band. Is expressed in several structures, including adult heart; anterior-posterior subdivision of organism; somatic muscle cell; and spermatozoon. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Orthologous to human SPEG (striated muscle enriched protein kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Obsc in Genome Data Viewer
    Location:
    60B1-60B2; 2-106 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23995543..24014254, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19883066..19901777, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene PAS kinase Neighboring gene uncharacterized protein Neighboring gene mir-1009 stem loop Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 4a

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tropomyosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adult somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to M-band IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in M band HDA PubMed 
    located_in M band IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    obscurin
    Names
    CG33519-PC
    CG33519-PD
    CG33519-PE
    CG33519-PF
    CG33519-PG
    CG33519-PH
    Obsc-PC
    Obsc-PD
    Obsc-PE
    Obsc-PF
    Obsc-PG
    Obsc-PH
    PROJECTIN-like
    Unc-89

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23995543..24014254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299877.1NP_001286806.1  obscurin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286806.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYP0
      Conserved Domains (10) summary
      PHA03247
      Location:493714
      PHA03247; large tegument protein UL36; Provisional
      cd00063
      Location:34333525
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:90260
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13325
      Location:275388
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:28673125
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:35783836
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      pfam07679
      Location:24022490
      I-set; Immunoglobulin I-set domain
      cd00096
      Location:24192423
      Ig; Ig strand B [structural motif]
      pfam13927
      Location:17971887
      Ig_3; Immunoglobulin domain
      cl11960
      Location:21002191
      Ig; Immunoglobulin domain
    2. NM_001299874.1NP_001286803.1  obscurin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286803.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYP0
      Conserved Domains (10) summary
      cd00096
      Location:11451212
      Ig; Immunoglobulin domain
      smart00408
      Location:15181585
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:31613415
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:37233815
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:90260
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:26922780
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:275388
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:31573415
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:38684126
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:27032772
      Ig; Immunoglobulin domain
    3. NM_001103970.2NP_001097440.1  obscurin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LGC9, A0A0B4LGE3, A0A0B4LGI5, A0A0B4LHF2, A8DYP0, Q1ZYJ8, Q59E65
      Conserved Domains (10) summary
      cd00063
      Location:37483840
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:90260
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:27172805
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:275388
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:31823440
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:38934151
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      pfam13927
      Location:14061487
      Ig_3; Immunoglobulin domain
      pfam16031
      Location:502596
      TonB_N; TonB N-terminal region
      cl26464
      Location:493690
      Atrophin-1; Atrophin-1 family
      cl28434
      Location:36543744
      I-set; Immunoglobulin I-set domain
    4. NM_001014545.3NP_001014545.3  obscurin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014545.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYP0
      Conserved Domains (10) summary
      cd00096
      Location:11461213
      Ig; Immunoglobulin domain
      smart00408
      Location:15191586
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:31623416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:37243816
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00160
      Location:91261
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam07679
      Location:26932781
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:276389
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:31583416
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:38694127
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:27042773
      Ig; Immunoglobulin domain
    5. NM_001299876.1NP_001286805.1  obscurin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286805.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYP0
      Conserved Domains (8) summary
      cd00096
      Location:237304
      Ig; Immunoglobulin domain
      smart00408
      Location:610677
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:22782532
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:28402932
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:18091897
      I-set; Immunoglobulin I-set domain
      cd14109
      Location:22742532
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:29853243
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:18201889
      Ig; Immunoglobulin domain
    6. NM_001299875.1NP_001286804.1  obscurin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8DYP0
      Conserved Domains (9) summary
      cd00096
      Location:892959
      Ig; Immunoglobulin domain
      smart00408
      Location:12651332
      IGc2; Immunoglobulin C-2 Type
      smart00220
      Location:29333187
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00063
      Location:34953587
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:24642552
      I-set; Immunoglobulin I-set domain
      cd13325
      Location:22135
      PH_unc89; unc89 pleckstrin homology (PH) domain
      cd14109
      Location:29293187
      PK_Unc-89_rpt1; Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cd14112
      Location:36403898
      STKc_Unc-89_rpt2; Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89
      cl11960
      Location:24752544
      Ig; Immunoglobulin domain