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    Egfrap EGFR adaptor protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3885637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Egfrapprovided by FlyBase
    Official Full Name
    EGFR adaptor proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053993
    Locus tag
    Dmel_CG33993
    See related
    AllianceGenome:FB:FBgn0053993
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13289; CG13290; CG33993; Dmel\CG33993; EGFRAP
    Summary
    Enables receptor tyrosine kinase binding activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway. Is active in apical cortex. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; anterior endoderm; embryonic/larval midgut primordium; and gut section. Orthologous to human TNS4 (tensin 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Egfrap in Genome Data Viewer
    Location:
    65A1-65A1; 3-16 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5933036..5950658, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5926136..5943758, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulator of chromosome condensation 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45439

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EGFRAP encodes a new negative regulator of the EGFR acting in both normal and oncogenic EGFR/Ras-driven tissue morphogenesis. Soler Beatty J, et al. PLoS Genet, 2021 Aug. PMID 34411095, Free PMC Article
    2. The long-term effects of a life-prolonging heat treatment on the Drosophila melanogaster transcriptome suggest that heat shock proteins extend lifespan. Sarup P, et al. Exp Gerontol, 2014 Feb. PMID 24316037
    3. Two distinct modes of guidance signalling during collective migration of border cells. Bianco A, et al. Nature, 2007 Jul 19. PMID 17637670
    4. Two independent duplications forming the Cyp307a genes in Drosophila. Sztal T, et al. Insect Biochem Mol Biol, 2007 Oct. PMID 17785192
    5. Platelet-derived growth factor/vascular endothelial growth factor receptor inactivation by sunitinib results in Tsc1/Tsc2-dependent inhibition of TORC1. Tran TA, et al. Mol Cell Biol, 2013 Oct. PMID 23878397, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables receptor tyrosine kinase binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EGFR adaptor protein
    Names
    CG33993-PA
    CG33993-PB
    Egfrap-PA
    Egfrap-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5933036..5950658 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038902.3 → NP_001033991.1  EGFR adaptor protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033991.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q29QP1, Q6NR09
      Conserved Domains (1) summary
      cd00173
      Location:286 → 364
      SH2; Src homology 2 (SH2) domain

    2. NM_001169881.1 → NP_001163352.1  EGFR adaptor protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163352.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QP1
      Conserved Domains (1) summary
      cd00173
      Location:123 → 201
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NR09.1 Q6NR09

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