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    Toll-9 Toll-9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40245, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Toll-9provided by FlyBase
    Official Full Name
    Toll-9provided by FlyBase
    Primary source
    FLYBASE:FBgn0036978
    Locus tag
    Dmel_CG5528
    See related
    AllianceGenome:FB:FBgn0036978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5528; CT17508; Dm Toll-9; Dmel\CG5528; dTLR9; dToll9; Tak/Toll-like; Tl-5; Tl-9; toll; Toll; Toll 9; TOLL 9; Toll-6; Toll9
    Summary
    Predicted to enable signaling receptor activity. Involved in signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in embryonic hemocyte anlage and yolk nucleus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to several human genes including TLR1 (toll like receptor 1) and TLR10 (toll like receptor 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Toll-9 in Genome Data Viewer
    Location:
    77B6-77B6; 3-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20361843..20366724, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20354943..20359824, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA primase subunit 2 Neighboring gene inturned Neighboring gene uncharacterized protein Neighboring gene Insulin degrading metalloproteinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration. Sakakibara Y, et al. iScience, 2023 Feb 17. PMID 36718365, Free PMC Article
    2. Rapidly Evolving Toll-3/4 Genes Encode Male-Specific Toll-Like Receptors in Drosophila. Levin TC, et al. Mol Biol Evol, 2017 Sep 1. PMID 28541576, Free PMC Article
    3. Lack of an antibacterial response defect in Drosophila Toll-9 mutant. Narbonne-Reveau K, et al. PLoS One, 2011 Feb 28. PMID 21386906, Free PMC Article
    4. The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol. Atkinson NS. Cells, 2023 May 30. PMID 37296629, Free PMC Article
    5. The chromosomes of Drosophila suzukii (Diptera: Drosophilidae): detailed photographic polytene chromosomal maps and in situ hybridization data. Drosopoulou E, et al. Mol Genet Genomics, 2019 Dec. PMID 31346719

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Toll-9
    Names
    CG5528-PA
    CG5528-PB
    CG5528-PC
    Toll-9-PA
    Toll-9-PB
    Toll-9-PC
    toll receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20361843..20366724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140957.4 → NP_649214.1  Toll-9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649214.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDT6, Q9VPH1
      Related
      FBpp0077898
      Conserved Domains (4) summary
      smart00255
      Location:751 → 891
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:449 → 536
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:288 → 311
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:477 → 536
      LRR_8; Leucine rich repeat

    2. NM_001259916.2 → NP_001246845.1  Toll-9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246845.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDT6, M9NDW9
      Conserved Domains (5) summary
      smart00255
      Location:677 → 817
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:375 → 462
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:358 → 372
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:157 → 189
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:403 → 462
      LRR_8; Leucine rich repeat

    3. NM_001259917.1 → NP_001246846.1  Toll-9, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246846.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B6IDT6, Q9VPH1
      Conserved Domains (4) summary
      smart00255
      Location:751 → 891
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:449 → 536
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:288 → 311
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:477 → 536
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDW9 M9NDW9
    Q9VPH1 Q9VPH1

    Gene LinkOut

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