Nlg3 Neuroligin 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Nlg3provided by FlyBase
Official Full Name: Neuroligin 3provided by FlyBase
Primary source: FLYBASE:FBgn0083963
Locus tag: Dmel_CG34127
See related: AllianceGenome:FB:FBgn0083963
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1062; CG14597; CG18291; CG32465; CG34127; Dmel\CG34127; dnlg3; DNlg3; DNLG3; neuroligin; Nlg-3; nlg3
Summary: Predicted to enable neurexin family protein binding activity and signaling receptor activity. Involved in neuromuscular junction development and synaptic vesicle endocytosis. Predicted to be active in cell surface and postsynaptic membrane. Is expressed in adult head. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to several human genes including NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (7570281..7639434, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (3396003..3465156, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables neurexin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic membrane assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

Names: CG34127-PB; CG34127-PC; Nlg3-PB; Nlg3-PC; drosokinin receptor; neuroligin3

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The following sections contain reference sequences that belong to a specific genome build. Explain