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    CG10669 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43069, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10669provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039329
    Locus tag
    Dmel_CG10669
    See related
    AllianceGenome:FB:FBgn0039329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10669
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic hindgut; embryonic/larval midgut; larval muscle system; and organism. Orthologous to human ZFP62 (ZFP62 zinc finger protein) and ZNF268 (zinc finger protein 268). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10669 in Genome Data Viewer
    Location:
    96D1-96D1; 3-87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25331363..25335243, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21157085..21160965, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene CHK domain ov1 Neighboring gene CHK domain ov2 Neighboring gene uncharacterized protein Neighboring gene rha Neighboring gene target of brain insulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster. Magwire MM, et al. PLoS Genet, 2012. PMID 23166512, Free PMC Article
    2. Genomic expansion and clustering of ZAD-containing C2H2 zinc-finger genes in Drosophila. Chung HR, et al. EMBO Rep, 2002 Dec. PMID 12446571, Free PMC Article
    3. Genome-Wide Mapping Targets of the Metazoan Chromatin Remodeling Factor NURF Reveals Nucleosome Remodeling at Enhancers, Core Promoters and Gene Insulators. Kwon SY, et al. PLoS Genet, 2016 Apr. PMID 27046080, Free PMC Article
    4. ZAD-Domain Is Essential for Nuclear Localization of Insulator Proteins in Drosophila melanogaster. Zolotarev NA, et al. Acta Naturae, 2016 Jul-Sep. PMID 27795848, Free PMC Article
    5. Innovation of heterochromatin functions drives rapid evolution of essential ZAD-ZNF genes in Drosophila. Kasinathan B, et al. Elife, 2020 Nov 10. PMID 33169670, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10669-PA
    CG10669-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25331363..25335243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170257.2 → NP_001163728.1  uncharacterized protein Dmel_CG10669, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163728.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3Y6, Q9VBR9
      Conserved Domains (4) summary
      COG5048
      Location:877 → 930
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:853 → 873
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:4 → 81
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:893 → 918
      zf-H2C2_2; Zinc-finger double domain

    2. NM_143131.4 → NP_651388.1  uncharacterized protein Dmel_CG10669, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3Y6, Q9VBR9
      Related
      FBpp0084222
      Conserved Domains (4) summary
      COG5048
      Location:877 → 930
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:853 → 873
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam07776
      Location:4 → 81
      zf-AD; Zinc-finger associated domain (zf-AD)
      pfam13465
      Location:893 → 918
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T3Y6 Q8T3Y6
    Q9VBR9 Q9VBR9

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