kumpel kin of rumpel [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: kumpelprovided by FlyBase
Official Full Name: kin of rumpelprovided by FlyBase
Primary source: FLYBASE:FBgn0250757
Locus tag: Dmel_CG42235
See related: AllianceGenome:FB:FBgn0250757
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14539; CG31090; CG42235; CG8932; CG8934; CG8951; CG8957; CG8966; Dmel\CG42235; dSLC5A10
Old locus tag: Dmel_CG31090; Dmel_CG8932; Dmel_CG8934; Dmel_CG8957; Dmel_CG8966
Summary: Enables solute:sodium symporter activity. Involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 96F7-96F8; 3-89 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (25907022..25921046)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (21732744..21746768)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables solute:sodium symporter activity	IGI Inferred from Genetic Interaction more info	PubMed
enables symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: kin of rumpel

Names: CG42235-PA; CG42235-PB; CG42235-PC; CG42235-PD; CG42235-PE; Na/iodide symporter-like; kumpel-PA; kumpel-PB; kumpel-PC; kumpel-PD; kumpel-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

25907022..25921046

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143190.4 → NP_651447.2 kin of rumpel, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651447.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VBK0

Conserved Domains (1) summary

cd11492
Location:105 → 645

SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
NM_143189.4 → NP_651446.2 kin of rumpel, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651446.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9VBK1

Conserved Domains (1) summary

cd11492
Location:105 → 646

SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
NM_170250.3 → NP_733129.1 kin of rumpel, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733129.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VBK2

Related

FBpp0288577

Conserved Domains (1) summary

cd11492
Location:105 → 644

SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
NM_001144639.3 → NP_001138111.1 kin of rumpel, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138111.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0Q4

Conserved Domains (1) summary

cd11492
Location:105 → 652

SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain
NM_001144640.2 → NP_001138112.1 kin of rumpel, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138112.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0Q5

Conserved Domains (1) summary

cd11492
Location:105 → 652

SLC5sbd_NIS-SMVT; Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain