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    Sf3b5 Splicing factor 3b subunit 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50007, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3b5provided by FlyBase
    Official Full Name
    Splicing factor 3b subunit 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0040534
    Locus tag
    Dmel_CG11985
    See related
    AllianceGenome:FB:FBgn0040534
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11985; Dmel\CG11985; sf3b5; SF3B5
    Summary
    Involved in regulation of gene expression and spermatogenesis. Part of SAGA complex and U2 snRNP. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human SF3B5 (splicing factor 3b subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sf3b5 in Genome Data Viewer
    Location:
    85C2-85C2; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9014972..9015341, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4840694..4841063, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Potassium channel modulatory factor 1 Neighboring gene uncharacterized protein Neighboring gene tango Neighboring gene antisense RNA:CR31429 Neighboring gene neuralized

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Wu H, et al. Proc Natl Acad Sci U S A, 2016 Apr 12. PMID 27035939, Free PMC Article
    2. What do the structures of GCN5-containing complexes teach us about their function? Helmlinger D, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32739556
    3. Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module. Cornelio-Parra DV, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32911111
    4. The Gcn5 complexes in Drosophila as a model for metazoa. Torres-Zelada EF, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Feb. PMID 32735945
    5. Defining gene networks controlling the maintenance and function of the differentiation niche by an in vivo systematic RNAi screen. Gao Y, et al. J Genet Genomics, 2019 Jan 20. PMID 30745214

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data support an independent function of SF3B5 in the transcription coactivator activity of the Spt-Ada-Gcn5 acetyltransferase that is separate from its role in splicing.
      Title: The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3b subunit 5
    Names
    CG11985-PA
    Sf3b5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9014972..9015341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143932.3 → NP_652189.1  splicing factor 3b subunit 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHI4
      UniProtKB/TrEMBL
      A0A1B2AKC8, Q4QPR9
      Related
      FBpp0081484
      Conserved Domains (1) summary
      pfam07189
      Location:3 → 77
      SF3b10; Splicing factor 3B subunit 10 (SF3b10)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHI4.1 Q9VHI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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