Pi3K68D Phosphatidylinositol 3-kinase 68D [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pi3K68Dprovided by FlyBase
Official Full Name: Phosphatidylinositol 3-kinase 68Dprovided by FlyBase
Primary source: FLYBASE:FBgn0015278
Locus tag: Dmel_CG11621
See related: AllianceGenome:FB:FBgn0015278
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11621; BcDNA:LD15217; CG11621; cpk; Cpk; Dmel\CG11621; dPI3k; dPI3K; dPIK; PI(3)K; Pi3K; PI3K; PI3K 68D; PI3K 68_D; PI3K-68D; PI3K-68D/E; pi3k68d; PI3K68D; PI3K_68D; PI[[3]]K
Summary: Enables several functions, including SH3 domain binding activity; phosphatidylinositol kinase activity; and small GTPase binding activity. Involved in cortical actin cytoskeleton organization; negative regulation of epidermal growth factor receptor signaling pathway; and phosphatidylinositol phosphate biosynthetic process. Located in endosome membrane. Is expressed in several structures, including adult brain; adult head; adult pars intercerebralis; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) and PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 68D4-68D6; 3-36 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11774650..11790013, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11767750..11783113, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results highlight an unexpected crosstalk whereby the normally growth-promoting, nutrient-sensing PI3K/TOR pathway suppresses tumour formation in neural stem cells with compromised cell polarity.
Title: Synergism between altered cortical polarity and the PI3K/TOR pathway in the suppression of tumour growth.
study concludes that tumor cells become dependent on PI3K function and that reduction of PI3K activity synthetically interferes with tumor growth.
Title: Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model.
evidence for a biological function for a class II PI3K by expressing this enzyme during development and by using deficiencies that remove the endogenous gene
Title: Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.
inhibiting Inr/PI3K signaling phenocopies the cellular and organismal effects of starvation, whereas activating this pathway bypasses the nutritional requirement for cell growth, causing starvation sensitivity at the organismal level
Title: Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 3-kinase 68D

Names: CG11621-PA; CG11621-PB; CG11621-PC; CG11621-PD; CG11621-PE; PI 3-kinase; PI3-kinase; Pi3K68D-PA; Pi3K68D-PB; Pi3K68D-PC; Pi3K68D-PD; Pi3K68D-PE; dPI 3-kinase; phosphotidylinositol 3 kinase 68D

NP_001163420.1

EC 2.7.1.137

EC 2.7.1.154

NP_001261724.1

EC 2.7.1.137

EC 2.7.1.154

NP_524028.2

EC 2.7.1.137

EC 2.7.1.154

NP_729743.1

EC 2.7.1.137

EC 2.7.1.154

NP_729745.1

EC 2.7.1.137

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

11774650..11790013 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169949.2 → NP_001163420.1 phosphatidylinositol 3-kinase 68D, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163420.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JNX6, Q7K3H0

Conserved Domains (7) summary

cd06884
Location:1611 → 1721

PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein

cd04012
Location:844 → 1021

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1751 → 1871

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:561 → 669

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00869
Location:1038 → 1202

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05166
Location:1235 → 1583

PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase

cl04813
Location:58 → 392

EIN3; Ethylene insensitive 3
NM_168475.3 → NP_729743.1 phosphatidylinositol 3-kinase 68D, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729743.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JNX6, Q7K3H0

Related

FBpp0075818

Conserved Domains (7) summary

cd06884
Location:1611 → 1721

PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein

cd04012
Location:844 → 1021

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1751 → 1871

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:561 → 669

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00869
Location:1038 → 1202

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05166
Location:1235 → 1583

PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase

cl04813
Location:58 → 392

EIN3; Ethylene insensitive 3
NM_079304.4 → NP_524028.2 phosphatidylinositol 3-kinase 68D, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524028.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7JNX6, Q7K3H0

Related

FBpp0075819

Conserved Domains (7) summary

cd06884
Location:1611 → 1721

PX_PI3K_C2_68D; The phosphoinositide binding Phox Homology Domain of Class II Phosphoinositide 3-Kinases similar to the Drosophila PI3K_68D protein

cd04012
Location:844 → 1021

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1751 → 1871

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:561 → 669

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00869
Location:1038 → 1202

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05166
Location:1235 → 1583

PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase

cl04813
Location:58 → 392

EIN3; Ethylene insensitive 3
NM_168476.3 → NP_729745.1 phosphatidylinositol 3-kinase 68D, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729745.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RR5

Related

FBpp0075817

Conserved Domains (1) summary

cl04813
Location:58 → 327

EIN3; Ethylene insensitive 3
NM_001274795.1 → NP_001261724.1 phosphatidylinositol 3-kinase 68D, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261724.1

Status: REVIEWED

UniProtKB/TrEMBL

Q95RR5

Conserved Domains (1) summary

cl04813
Location:58 → 327

EIN3; Ethylene insensitive 3