dlg1 discs large 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: dlg1provided by FlyBase
Official Full Name: discs large 1provided by FlyBase
Primary source: FLYBASE:FBgn0001624
Locus tag: Dmel_CG1725
See related: AllianceGenome:FB:FBgn0001624
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 11; anon-EST:Posey93; anon-WO03040301.258; anon-WO03040301.260; anon-WO03040301.268; CG1725; CG1730; CPD; d. lg.-1; Discs Large; Discs-large; dlg; Dlg; DLG; dlg-1; dlg-A; Dlg-A; DLG-A; Dlg1; DLG1; dlgA; DlgA; dlgS97; DlgS97; Dmel\CG1725; Drodlg; l(1)10Bf; l(1)bwn; l(1)d.lg-1; l(1)d.lg.-1; l(1)discs large; l(1)dlg; l(1)dlg-1; l(1)dlg1; l(1)G0276; l(1)G0342; l(1)G0456; l(1)G19; l(1)l.pr.-2; l(1)L11; l(1)lpr-2; misb; PSD-95; PSD95; SAP97
Summary: Predicted to enable protein kinase binding activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; basal protein localization; and oogenesis. Located in several cellular components, including apicolateral plasma membrane; lateral plasma membrane; and tight junction. Is active in type Ib terminal bouton. Colocalizes with presynaptic membrane. Is expressed in several structures, including epithelial cell; eye photoreceptor cell; ganglia; neuron projection bundle; and synaptic neuropil domain. Used to study benign neoplasm; cancer; carcinoma; chromosome 3q29 microdeletion syndrome; and developmental disorder of mental health. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; invasive ductal carcinoma; and non-syndromic X-linked intellectual disability 90. Orthologous to several human genes including DLG1 (discs large MAGUK scaffold protein 1); DLG3 (discs large MAGUK scaffold protein 3); and DLG4 (discs large MAGUK scaffold protein 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 10B6-10B10; 1-34 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11369665..11409776)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11263698..11303809)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for a nuclear role for Drosophila Dlg as a regulator of the NURF complex.
Title: Evidence for a nuclear role for Drosophila Dlg as a regulator of the NURF complex.
The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Title: The Basolateral Polarity Module Promotes Slit Diaphragm Formation in Drosophila Nephrocytes, a Model of Vertebrate Podocytes.
Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis.
Title: Electrostatic plasma membrane targeting contributes to Dlg function in cell polarity and tumorigenesis.
Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density.
Title: Molecular and cellular correlates in Kv channel clustering: entropy-based regulation of cluster ion channel density.
the Scribble/Dlg module plays multiple roles in polarity initiation
Title: Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.
Scrib and Dlg are key components of the tricellular junction.
Title: Scribble and Discs Large mediate tricellular junction formation.
Data suggest that the discs large 1 protein (Dlg) and the clathrin-mediated endocytic (CME) machinery downregulate epidermal growth factor receptor (EGFR) signaling.
Title: The Dlg Module and Clathrin-Mediated Endocytosis Regulate EGFR Signaling and Cyst Cell-Germline Coordination in the Drosophila Testis.
findings reveal that Scrib's PDZ1 domain functions in the interaction with Gukh and that the Scrib-Gukh interaction has a key role in epithelial tissue development in Drosophila
Title: Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.
The authors find that the tumor suppressor Discs large (Dlg) links the Par complex component atypical Protein Kinase C (aPKC) to the essential spindle orientation factor GukHolder (GukH).
Title: Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division.
The structure of dlg1 reveals that the core of the dimer is formed by a distinctive six-helix assembly, involving all three conserved helices from each subunit (monomer). The homodimer interface is extended by the C-terminal tail of the L27 domain of Dlg1, which forms a two-stranded antiparallel beta-sheet. The structure reconciles and provides a structural context for a large body of available mutational data.
Title: Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables guanylate kinase activity	TAS Traceable Author Statement more info	PubMed
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterior/posterior axis specification, follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric protein localization involved in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basal protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment involved in pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	TAS Traceable Author Statement more info	PubMed
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment or maintenance of polarity of follicular epithelium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment or maintenance of polarity of larval imaginal disc epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gravitaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of a polarized epithelium	TAS Traceable Author Statement more info	PubMed
involved_in morphogenesis of follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in morphogenesis of larval imaginal disc epithelium	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole plasm protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive phototaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in septate junction assembly	TAS Traceable Author Statement more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	HDA more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in leading edge membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in smooth septate junction	IDA Inferred from Direct Assay more info	PubMed
located_in subsynaptic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in tricellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in type I terminal bouton	IDA Inferred from Direct Assay more info	PubMed
is_active_in type Ib terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: discs large 1

Names: CG1725-PA; CG1725-PB; CG1725-PC; CG1725-PD; CG1725-PE; CG1725-PF; CG1725-PG; CG1725-PH; CG1725-PI; CG1725-PJ; CG1725-PK; CG1725-PL; CG1725-PM; CG1725-PN; CG1725-PO; CG1725-PP; CG1725-PQ; CG1725-PR; CG1725-PS; CG1725-PT; CG1725-PU; Disc-Large; Discs-large; Discs-large 1; disc large; disclarge; discs large; discslarge; disk large; dlg1-PA; dlg1-PB; dlg1-PC; dlg1-PD; dlg1-PE; dlg1-PF; dlg1-PG; dlg1-PH; dlg1-PI; dlg1-PJ; dlg1-PK; dlg1-PL; dlg1-PM; dlg1-PN; dlg1-PO; dlg1-PP; dlg1-PQ; dlg1-PR; dlg1-PS; dlg1-PT; dlg1-PU; lethal(1)benign wing imaginal disc neoplasm; lethal(1)discs large; lethal(1)discs-large; lethal(2)discs large

NP_001096955.1

EC 2.7.4.8

NP_001096956.1

EC 2.7.4.8

NP_001162718.1

EC 2.7.4.8

NP_001162719.1

EC 2.7.4.8

NP_001162720.1

EC 2.7.4.8

NP_001245622.1

EC 2.7.4.8

NP_001245623.1

EC 2.7.4.8

NP_001259446.1

EC 2.7.4.8

NP_001259447.1

EC 2.7.4.8

NP_001259448.1

EC 2.7.4.8

NP_001259449.1

EC 2.7.4.8

NP_511120.2

EC 2.7.4.8

NP_727518.1

EC 2.7.4.8

NP_727519.1

EC 2.7.4.8

NP_727520.1

EC 2.7.4.8

NP_996402.1

EC 2.7.4.8

NP_996403.1

EC 2.7.4.8

NP_996404.1

EC 2.7.4.8

NP_996405.1

EC 2.7.4.8

NP_996406.1

EC 2.7.4.8

NP_996407.1

EC 2.7.4.8

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11369665..11409776

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001103486.3 → NP_001096956.1 discs large 1, isoform L [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Conserved Domains (6) summary

cd11861
Location:573 → 633

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:763 → 933

GuKc; Guanylate kinase homologues

smart00228
Location:165 → 251

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:453 → 531

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:755 → 933

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1
NM_206683.4 → NP_996406.1 discs large 1, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4A8, A4V4B0, A8JUR9, A8JUS0, C7LAH6, P31007, Q7KV38, Q7KV39, Q7KV40, Q7YXH8, Q8SY37, Q8T0C6, Q95TF5, Q9VYZ4, Q9VYZ5, Q9VYZ6

Conserved Domains (6) summary

cd11861
Location:624 → 684

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:787 → 957

GuKc; Guanylate kinase homologues

smart00228
Location:216 → 302

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:504 → 582

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:779 → 957

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1
NM_206681.4 → NP_996404.1 discs large 1, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Conserved Domains (6) summary

cd11861
Location:565 → 625

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:728 → 898

GuKc; Guanylate kinase homologues

smart00228
Location:157 → 243

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:445 → 523

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:720 → 898

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1
NM_167280.2 → NP_727518.1 discs large 1, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Related

FBpp0073339

Conserved Domains (1) summary

pfam09058
Location:4 → 62

L27_1; L27_1
NM_001272520.1 → NP_001259449.1 discs large 1, isoform U [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9PEB3

Conserved Domains (1) summary

pfam09058
Location:4 → 62

L27_1; L27_1
NM_206680.2 → NP_996403.1 discs large 1, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Conserved Domains (1) summary

pfam09058
Location:4 → 62

L27_1; L27_1
NM_206679.2 → NP_996402.1 discs large 1, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Conserved Domains (1) summary

pfam09058
Location:4 → 62

L27_1; L27_1
NM_001169249.3 → NP_001162720.1 discs large 1, isoform O [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

C1C536

Conserved Domains (1) summary

pfam09058
Location:4 → 62

L27_1; L27_1
NM_167281.2 → NP_727519.1 discs large 1, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Related

FBpp0073340

Conserved Domains (3) summary

smart00228
Location:513 → 599

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:625 → 714

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09058
Location:303 → 359

L27_1; L27_1
NM_001169247.1 → NP_001162718.1 discs large 1, isoform M [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJH5

Conserved Domains (4) summary

cd11861
Location:862 → 922

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00228
Location:454 → 540

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:742 → 820

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam09058
Location:303 → 359

L27_1; L27_1
NM_001103485.3 → NP_001096955.1 discs large 1, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Conserved Domains (5) summary

cd11861
Location:565 → 625

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:728 → 898

GuKc; Guanylate kinase homologues

smart00228
Location:157 → 243

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:445 → 523

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:720 → 898

Guanylate_kin; Guanylate kinase
NM_001272518.1 → NP_001259447.1 discs large 1, isoform S [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJH6

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:777 → 947

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:769 → 947

Guanylate_kin; Guanylate kinase
NM_001258694.2 → NP_001245623.1 discs large 1, isoform Q [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9NGZ2

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:792 → 962

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:784 → 962

Guanylate_kin; Guanylate kinase
NM_206682.4 → NP_996405.1 discs large 1, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9NGZ2

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:792 → 962

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:784 → 962

Guanylate_kin; Guanylate kinase
NM_078565.5 → NP_511120.2 discs large 1, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJH6

Related

FBpp0073341

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:777 → 947

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:769 → 947

Guanylate_kin; Guanylate kinase
NM_001272517.1 → NP_001259446.1 discs large 1, isoform R [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9PHK8

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:777 → 947

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:769 → 947

Guanylate_kin; Guanylate kinase
NM_206684.4 → NP_996407.1 discs large 1, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJH6

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:777 → 947

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:769 → 947

Guanylate_kin; Guanylate kinase
NM_001272519.1 → NP_001259448.1 discs large 1, isoform T [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

M9PJI4

Conserved Domains (5) summary

cd11861
Location:612 → 672

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:760 → 930

GuKc; Guanylate kinase homologues

smart00228
Location:48 → 134

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:492 → 570

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:752 → 930

Guanylate_kin; Guanylate kinase
NM_167282.4 → NP_727520.1 discs large 1, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P31007

Related

FBpp0073342

Conserved Domains (5) summary

cd11861
Location:612 → 672

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:785 → 955

GuKc; Guanylate kinase homologues

smart00228
Location:48 → 134

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:492 → 570

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:777 → 955

Guanylate_kin; Guanylate kinase
NM_001169248.2 → NP_001162719.1 discs large 1, isoform N [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E1JJH6

Conserved Domains (5) summary

cd11861
Location:604 → 664

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:777 → 947

GuKc; Guanylate kinase homologues

smart00228
Location:40 → 126

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:484 → 562

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:769 → 947

Guanylate_kin; Guanylate kinase
NM_001258693.1 → NP_001245622.1 discs large 1, isoform P [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

E8NH13

Conserved Domains (5) summary

cd11861
Location:612 → 672

SH3_DLG-like; Src Homology 3 domain of Disks large homolog proteins

smart00072
Location:800 → 970

GuKc; Guanylate kinase homologues

smart00228
Location:48 → 134

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:492 → 570

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:792 → 970

Guanylate_kin; Guanylate kinase

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
C1C536		C1C536
E1JJH5		E1JJH5
E1JJH6		E1JJH6
E8NH13		E8NH13
M9NGZ2		M9NGZ2
M9PEB3		M9PEB3
M9PHK8		M9PHK8
M9PJI4		M9PJI4
P31007.2		P31007
Q4PLW2		Q4PLW2