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    CG4592 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34317, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4592provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032162
    Locus tag
    Dmel_CG4592
    See related
    AllianceGenome:FB:FBgn0032162
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4592
    Summary
    Predicted to enable delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in mitochondrion. Is expressed in adult head. Orthologous to human ECI1 (enoyl-CoA delta isomerase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4592 in Genome Data Viewer
    Location:
    30F1-30F1; 2-38 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (9921633..9922860)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (9921633..9922860)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene TbCMF46 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Many P-element insertions affect wing shape in Drosophila melanogaster. Weber K, et al. Genetics, 2005 Mar. PMID 15545659, Free PMC Article
    2. Relish-facilitated lncRNA-CR11538 suppresses Drosophila Imd immune response and maintains immune homeostasis via decoying Relish away from antimicrobial peptide promoters. Huang Y, et al. Dev Comp Immunol, 2024 Feb. PMID 37956726
    3. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article
    4. Identification of novel genes associated with longevity in Drosophila melanogaster - a computational approach. Hall BS, et al. Aging (Albany NY), 2019 Dec 3. PMID 31794428, Free PMC Article
    5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4592-PA
    CG4592-PB
    NP_001260306.1
    NP_609324.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      9921633..9922860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273377.1 → NP_001260306.1  uncharacterized protein Dmel_CG4592, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN20, Q9VL66
      Conserved Domains (1) summary
      cl23717
      Location:43 → 284
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_135480.4 → NP_609324.2  uncharacterized protein Dmel_CG4592, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609324.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NN20, Q9VL66
      Related
      FBpp0079475
      Conserved Domains (1) summary
      cl23717
      Location:43 → 284
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SQ5 Q95SQ5
    Q9VL66 Q9VL66

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