nAChRbeta1 nicotinic Acetylcholine Receptor beta1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: nAChRbeta1provided by FlyBase
Official Full Name: nicotinic Acetylcholine Receptor beta1provided by FlyBase
Primary source: FLYBASE:FBgn0000038
Locus tag: Dmel_CG11348
See related: AllianceGenome:FB:FBgn0000038
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AChR; AchR64B; AChR64B; Acr64B; AcrD; ard; Ard; ARD; beta 64B; beta1 nAChR; CG11348; CG11348-PA; CG12606; Dbeta1; Dmel\CG11348; nAChR; nAChR-beta64B; nAChRDbeta1; nAChR_beta1; nAcR64B; nAcRbeta-64B
Summary: Predicted to enable excitatory extracellular ligand-gated monoatomic ion channel activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in cholinergic synaptic transmission. Located in postsynaptic membrane. Is expressed in several structures, including adult head; cell body rind region; ganglia; optic lobe narrow field columnar neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; cocaine abuse; congenital myasthenic syndrome (multiple); and respiratory system cancer (multiple). Orthologous to several human genes including CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64B6-64B6; 3-12 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4429349..4435993)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4429349..4435993)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, cholinergic	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: nicotinic acetylcholine receptor beta1

Names: AChR protein of drosophila; CG11348-PA; CG11348-PB; nAChRbeta1-PA; nAChRbeta1-PB; nicotinic acetylcholine receptor beta 64B; nicotinic acetylcholine receptorb-64B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

4429349..4435993

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079203.3 → NP_523927.2 nicotinic acetylcholine receptor beta1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523927.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P04755, Q9VZC3

UniProtKB/TrEMBL

E8NHB5

Related

FBpp0073155

Conserved Domains (3) summary

TIGR00860
Location:8 → 500

LIC; Cation transporter family protein

pfam02931
Location:28 → 236

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:243 → 498

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_168086.2 → NP_728994.1 nicotinic acetylcholine receptor beta1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_728994.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VZC4

Related

FBpp0073156