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    Flacc Fl(2)d-associated complex component [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Flaccprovided by FlyBase
    Official Full Name
    Fl(2)d-associated complex componentprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030974
    Locus tag
    Dmel_CG7358
    See related
    AllianceGenome:FB:FBgn0030974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7358; Dmel\CG7358; flacc; xio
    Summary
    Involved in mRNA processing; regulation of alternative mRNA splicing, via spliceosome; and sex determination. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; ganglia; and mesoderm. Orthologous to human ZC3H13 (zinc finger CCCH-type containing 13). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Flacc in Genome Data Viewer
    Location:
    17F2-17F2; 1-61 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18888978..18893636, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18783011..18787669, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Dorado Neighboring gene uncharacterized protein Neighboring gene Succinate dehydrogenase, subunit B (iron-sulfur)-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xio is a component of the Drosophila sex determination pathway and RNA N(6)-methyladenosine methyltransferase complex. Guo J, et al. Proc Natl Acad Sci U S A, 2018 Apr 3. PMID 29555755, Free PMC Article
    2. Hakai is required for stabilization of core components of the m(6)A mRNA methylation machinery. Bawankar P, et al. Nat Commun, 2021 Jun 18. PMID 34145251, Free PMC Article
    3. Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-Cell RNA Sequencing. Li H, et al. Cell, 2017 Nov 16. PMID 29149607, Free PMC Article
    4. Role of Hakai in m(6)A modification pathway in Drosophila. Wang Y, et al. Nat Commun, 2021 Apr 12. PMID 33846330, Free PMC Article
    5. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d. Knuckles P, et al. Genes Dev, 2018 Mar 1. PMID 29535189, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sex determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA N6-methyladenosine methyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fl(2)d-associated complex component
    Names
    CG7358-PA
    CG7358-PB
    CG7358-PC
    Flacc-PA
    Flacc-PB
    Flacc-PC
    xiong

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18888978..18893636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298489.1 → NP_001285418.1  Fl(2)d-associated complex component, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JFQ1

    2. NM_133111.2 → NP_573339.1  Fl(2)d-associated complex component, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWN4, X2JFQ1, X2JG10
      Related
      FBpp0074423

    3. NM_001298490.1 → NP_001285419.1  Fl(2)d-associated complex component, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285419.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JG10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWN4.1 Q9VWN4

    Gene LinkOut

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