ND-23 NADH dehydrogenase (ubiquinone) 23 kDa subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: ND-23provided by FlyBase
Official Full Name: NADH dehydrogenase (ubiquinone) 23 kDa subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0017567
Locus tag: Dmel_CG3944
See related: AllianceGenome:FB:FBgn0017567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3944; Dmel\CG3944; dNDUFS8; ND 23; ND23; NDUFS8; NUIM
Summary: Predicted to enable 4 iron, 4 sulfur cluster binding activity and oxidoreductase activity, acting on NAD(P)H. Predicted to contribute to NADH dehydrogenase (ubiquinone) activity and NADH dehydrogenase activity. Involved in mitochondrial ATP synthesis coupled electron transport. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelial tube; gut section; and larval muscle cell. Used to study Leigh disease. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 2. Orthologous to human NDUFS8 (NADH:ubiquinone oxidoreductase core subunit S8). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15836048..15837117, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11661770..11662839, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial ATP synthesis coupled electron transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	IC Inferred by Curator more info	PubMed
involved_in mitochondrial respiratory chain complex I assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IC Inferred by Curator more info	PubMed
located_in mitochondrion	HDA more info	PubMed
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed

Names: CG3944-PA; COMPLEX I: 23 kDa subunit; NADH ubiquinone oxidoreductase 23 kDa; NADH-UBIQUINONE OXIDOREDUCTASE 23 KDA SUBUNIT; NADH: UBIQUINONE REDUCTASE 23 KD SUBUNIT PRECURSOR; NADH:ubiquinone oxidoreductase 23 kDa subunit; NADH:ubiquinone reductase 23kD subunit precursor; ND-23-PA

NP_524719.1

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