Dsp1 Dorsal switch protein 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dsp1provided by FlyBase
Official Full Name: Dorsal switch protein 1provided by FlyBase
Primary source: FLYBASE:FBgn0278608
Locus tag: Dmel_CG12223
See related: AllianceGenome:FB:FBgn0278608
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12223; Dmel\CG12223; dsp1; DSP1; hmg; Hmg14B; Hmg14D; HMGB1; HMGD1; ssrp2; Ssrp2
Summary: Enables DNA binding activity, bending; DNA-binding transcription factor binding activity; and TBP-class protein binding activity. Involved in several processes, including leg disc development; negative regulation of RNA polymerase II transcription preinitiation complex assembly; and negative regulation of antimicrobial humoral response. Located in nucleus and polytene chromosome. Is expressed in several structures, including adult brain cell body rind; adult head; ganglia; germline cell; and gut section. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; congestive heart failure; and syndromic microphthalmia 13. Orthologous to several human genes including HMGB3 (high mobility group box 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 14B14-14B15; 1-53 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (16333612..16340624)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (16227645..16234657)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila.
Title: The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila.
Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos
Title: Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos.
While Dorsal seems to be nuclearly localized in ventral nuclei, it is actively shuttling into and out of all nuclei, including nuclei on the dorsal side.
Title: Nucleocytoplasmic shuttling mediates the dynamic maintenance of nuclear Dorsal levels during Drosophila embryogenesis.
Molecular modeling was used to compare the tertiary structure of Dsp1 with two other Drosophila proteins.
Title: Functional conservation of Rel binding sites in drosophilid genomes.
Scr gene expression is influenced by direct interaction between DSP1 and two Scr regulation elements
Title: DSP1, a Drosophila HMG protein, is involved in spatiotemporal expression of the homoeotic gene Sex combs reduced.
binding of DSP1 to Polycomb response elements is important for the recruitment of Polycomb group proteins
Title: Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.
involved in the regulation of the kni gap gene
Title: DSP1 interacts with bicoid for knirps enhancement.
analysis of the interaction between the dorsal rel homology domain and HMG boxes of DSP1 protein
Title: Mutagenesis analysis of the interaction between the dorsal rel homology domain and HMG boxes of DSP1 protein.
affects gene expression regulation in Drosophila.
Title: [Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1].
DSP1 and corto proteins co-localize at 91 sites on polytene chromosomes and co-immunoprecipitate in embryos.
Title: Corto and DSP1 interact and bind to a maintenance element of the Scr Hox gene: understanding the role of Enhancers of trithorax and Polycomb.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding, bending	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA unwinding involved in DNA replication	NAS Non-traceable Author Statement more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leg disc development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of RNA polymerase II transcription preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of antimicrobial humoral response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in segment specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dorsal switch protein 1

Names: CG12223-PA; CG12223-PB; CG12223-PC; CG12223-PD; CG12223-PE; CG12223-PF; CG12223-PG; Dsp1-PA; Dsp1-PB; Dsp1-PC; Dsp1-PD; Dsp1-PE; Dsp1-PF; Dsp1-PG; Hmg14B; dorsal switch protein-1; structure specific recognition protein 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

16333612..16340624

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206762.3 → NP_996485.1 dorsal switch protein 1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996485.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4L8, Q23998, Q24285, Q24537, Q95SD7

UniProtKB/TrEMBL

C9QP38

Conserved Domains (2) summary

cd01390
Location:271 → 335

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:178 → 248

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_080715.4 → NP_542446.2 dorsal switch protein 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_542446.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24537

Related

FBpp0088320

Conserved Domains (2) summary

cd01390
Location:263 → 327

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:170 → 240

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_167503.3 → NP_727960.1 dorsal switch protein 1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24537

Related

FBpp0088319

Conserved Domains (2) summary

cd01390
Location:263 → 327

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:170 → 240

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_167504.2 → NP_727961.1 dorsal switch protein 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727961.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24537

Related

FBpp0088318

Conserved Domains (2) summary

cd01390
Location:263 → 327

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:170 → 240

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_001298393.1 → NP_001285322.1 dorsal switch protein 1, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285322.1

Status: REVIEWED

UniProtKB/TrEMBL

F2FBA6

Conserved Domains (2) summary

cd01390
Location:264 → 328

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:171 → 241

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_167502.3 → NP_727959.2 dorsal switch protein 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727959.2

Status: REVIEWED

UniProtKB/TrEMBL

F2FBA6

Conserved Domains (2) summary

cd01390
Location:264 → 328

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:171 → 241

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
NM_001144731.3 → NP_001138203.1 dorsal switch protein 1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138203.1

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0Z0, C9QP38

Conserved Domains (2) summary

cd01390
Location:275 → 339

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

cl00082
Location:182 → 252

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...