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    Fpps Farnesyl pyrophosphate synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36209, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fppsprovided by FlyBase
    Official Full Name
    Farnesyl pyrophosphate synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025373
    Locus tag
    Dmel_CG12389
    See related
    AllianceGenome:FB:FBgn0025373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12389; Dmel\CG12389; DmFPPS; DmFPPSase; DmFPS; fpps; FPPS; fps; FPS; l(2)k06103; v(2)k03514
    Summary
    Predicted to enable dimethylallyltranstransferase activity and geranyltranstransferase activity. Involved in germ cell migration. Located in mitochondrial matrix. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Fpps in Genome Data Viewer
    Location:
    47F1-47F1; 2-64 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11305511..11307528, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7193016..7195033, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 47b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene no mechanoreceptor potential A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression and characterization of a dipteran farnesyl diphosphate synthase. Sen SE, et al. Insect Biochem Mol Biol, 2007 Nov. PMID 17916506
    2. Mitochondrial targeting of farnesyl diphosphate synthase is a widespread phenomenon in eukaryotes. Martín D, et al. Biochim Biophys Acta, 2007 Mar. PMID 17198737
    3. The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms. Williams MJ, et al. Cells, 2022 Mar 11. PMID 35326421, Free PMC Article
    4. A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes. Henry O, et al. Bioorg Med Chem, 2009 Jul 1. PMID 19447628, Free PMC Article
    5. Zoledronate Extends Health Span and Survival via the Mevalonate Pathway in a FOXO-dependent Manner. Chen Z, et al. J Gerontol A Biol Sci Med Sci, 2022 Aug 12. PMID 34137822, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Farnesyl diphosphate synthase (FPPS) of the dipteran Drosophila melanogaster has been cloned and its catalytic properties have been assessed.
      Title: Cloning, expression and characterization of a dipteran farnesyl diphosphate synthase.
    2. mitochondrial targeting of FPS may be widespread among eukaryotes
      Title: Mitochondrial targeting of farnesyl diphosphate synthase is a widespread phenomenon in eukaryotes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables geranyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in farnesyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    farnesyl pyrophosphate synthase
    Names
    CG12389-PA
    Fpps-PA
    farnesyl diphosphase synthase
    farnesyl diphosphate synthase
    NP_477380.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11305511..11307528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058032.5 → NP_477380.1  farnesyl pyrophosphate synthase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KAK2, Q7KN61
      Related
      FBpp0087266
      Conserved Domains (1) summary
      pfam00348
      Location:119 → 377
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KAK2 Q7KAK2
    Q7KN61 Q7KN61

    Gene LinkOut

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