Tace tace [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Taceprovided by FlyBase
Official Full Name: taceprovided by FlyBase
Primary source: FLYBASE:FBgn0039734
Locus tag: Dmel_CG7908
See related: AllianceGenome:FB:FBgn0039734
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ADAM17; CG7908; CT23908; Dmel\CG7908; DTACE; tace; TACE; TNF-alpha converting enzyme
Summary: Enables metalloendopeptidase activity. Involved in several processes, including cell surface receptor signaling pathway; commissural neuron axon guidance; and membrane protein ectodomain proteolysis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in spermatozoon and ventral nerve cord. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; and type 2 diabetes mellitus. Orthologous to human ADAM17 (ADAM metallopeptidase domain 17). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 99D1-99D1; 3-100 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (30000530..30003678)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25826252..25829400)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TACE cleaved DNlg3 exclusively at its extracellular acetylcholinesterase-like domain to generate the N-terminal fragment and the short membrane-anchored fragment (sDNlg3).
Title: Proteolytic maturation of Drosophila Neuroligin 3 by tumor necrosis factor α-converting enzyme in the nervous system.
TACE, which is elevated in expression in the developing nervous system, can efficiently activate Notch in a ligand-independent manner.
Title: Kuz and TACE can activate Notch independent of ligand.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tace

Names: CG7908-PA; CG7908-PB; Tace-PA; Tace-PB; tumor necrosis factor-alpha-converting enzyme

NP_651759.4

EC 3.4.24.-

NP_733334.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

30000530..30003678

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143502.4 → NP_651759.4 tace, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651759.4

Status: REVIEWED

UniProtKB/TrEMBL

E0R7M1

Conserved Domains (2) summary

pfam01562
Location:50 → 162

Pep_M12B_propep; Reprolysin family propeptide

cl00064
Location:223 → 256

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
NM_170455.3 → NP_733334.1 tace, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733334.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q868A7, Q8IMJ9, Q95RZ4, Q9VAC5

Related

FBpp0084917

Conserved Domains (5) summary

cd04270
Location:223 → 470

ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.

cd14246
Location:576 → 633

ADAM17_MPD; Membrane-proximal domain of a disintegrin and metalloprotease 17 (ADAM17)

pfam00200
Location:477 → 552

Disintegrin; Disintegrin

pfam01562
Location:50 → 162

Pep_M12B_propep; Reprolysin family propeptide

pfam13574
Location:244 → 456

Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like