yip2 yippee interacting protein 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: yip2provided by FlyBase
Official Full Name: yippee interacting protein 2provided by FlyBase
Primary source: FLYBASE:FBgn0040064
Locus tag: Dmel_CG4600
See related: AllianceGenome:FB:FBgn0040064
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ACAA; CG4600; Dmel\CG4600; Yip2; YIP2
Summary: Predicted to enable acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and negative regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; epithelium; germline cell; gut section; and visceral mesoderm derivative. Orthologous to human ACAA2 (acetyl-CoA acyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 30E4-30E4; 2-37 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9915253..9917220)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9915253..9917220)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables acetyl-CoA C-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetyl-CoA C-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: yippee interacting protein 2

Names: CG4600-PA; acetyl-CoA acyltransferase; yip2-PA

NP_523528.1

EC 2.3.-.-

EC 2.3.1.-

EC 2.3.1.16

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9915253..9917220

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078804.4 → NP_523528.1 yippee interacting protein 2 [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523528.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VL70

Related

FBpp0079472

Conserved Domains (2) summary

PRK05790
Location:6 → 398

PRK05790; putative acyltransferase; Provisional

cd00751
Location:9 → 397

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...