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    Dr Drop [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45285, updated on 9-Dec-2024

    Summary

    Official Symbol
    Drprovided by FlyBase
    Official Full Name
    Dropprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000492
    Locus tag
    Dmel_CG1897
    See related
    AllianceGenome:FB:FBgn0000492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    153515_at; 99B; CG1897; Dmel\CG1897; Dr/msh; Dr/Msh; l(3)FA30; ltt; msh; Msh; msh-1; msh1; Msx
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including imaginal disc-derived male genitalia development; nervous system development; and wing disc development. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; glial cell; gut section; larval neuromere; and neuroblasts. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; parietal foramina; tooth and nail syndrome; and tooth disease (multiple). Orthologous to human MSX1 (msh homeobox 1) and MSX2 (msh homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    99B3-99B3; 3-99 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29556386..29565244)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25382108..25390966)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 20 kDa subunit-like Neighboring gene long non-coding RNA:CR43613 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in central nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation, imaginal disc IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ectoderm development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in embryonic morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle organ development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pattern specification process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ventral cord development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in ventral cord development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in wing and notum subfield formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wing disc pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    drop
    Names
    CG1897-PA
    Dr-PA
    Dr-distal
    lottchen
    muscle segment homeobox
    muscle specific homeobox
    muscle-specific homeodomain
    muscle-specific homeodomain 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29556386..29565244
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057976.3NP_477324.1  drop [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477324.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03372, Q24481, Q8T0H1, Q9VAK4
      Related
      FBpp0084807
      Conserved Domains (1) summary
      pfam00046
      Location:424477
      Homeobox; Homeobox domain