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    CG12321 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12321provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038577
    Locus tag
    Dmel_CG12321
    See related
    AllianceGenome:FB:FBgn0038577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG12321
    Summary
    Predicted to be involved in proteasome assembly. Predicted to be active in cytosol and nucleus. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 4. Orthologous to human PSMG2 (proteasome assembly chaperone 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12321 in Genome Data Viewer
    Location:
    90F6-90F6; 3-62 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18187805..18188707, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14013527..14014429, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene well-rounded Neighboring gene cadmus Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene Mediator complex subunit 17 Neighboring gene uncharacterized protein Neighboring gene Sequence-specific single-stranded DNA-binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a Drosophila proteasome regulatory network. Lundgren J, et al. Mol Cell Biol, 2005 Jun. PMID 15899868, Free PMC Article
    2. Wolbachia and Virus Alter the Host Transcriptome at the Interface of Nucleotide Metabolism Pathways. Lindsey ARI, et al. mBio, 2021 Feb 9. PMID 33563832, Free PMC Article
    3. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
    4. MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer. Tsuboyama N, et al. Genome Biol, 2022 Sep 30. PMID 36180891, Free PMC Article
    5. Identification of GOLPH3 Partners in Drosophila Unveils Potential Novel Roles in Tumorigenesis and Neural Disorders. Sechi S, et al. Cells, 2021 Sep 6. PMID 34571985, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in proteasome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12321-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18187805..18188707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142428.3 → NP_650685.1  uncharacterized protein Dmel_CG12321 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650685.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEC2
      Related
      FBpp0083036
      Conserved Domains (1) summary
      pfam09754
      Location:25 → 126
      PAC2; PAC2 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEC2 Q9VEC2

    Gene LinkOut

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