U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    WDR79 WD repeat domain 79 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33865, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    WDR79provided by FlyBase
    Official Full Name
    WD repeat domain 79provided by FlyBase
    Primary source
    FLYBASE:FBgn0031782
    Locus tag
    Dmel_CG9226
    See related
    AllianceGenome:FB:FBgn0031782
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9226; Dmel\CG9226; dWDR79; p70
    Summary
    Enables box C/D sno(s)RNA binding activity. Involved in Cajal body organization. Located in Cajal body. Used to study motor neuron disease. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 3; colorectal cancer; head and neck squamous cell carcinoma; lung non-small cell carcinoma; and ovarian cancer. Orthologous to human WRAP53 (WD repeat containing antisense to TP53). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See WDR79 in Genome Data Viewer
    Location:
    26B7-26B7; 2-18 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6125879..6127775, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6125879..6127775, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stathmin Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2/3 complex, subunit 4 Neighboring gene tectonic Neighboring gene B9d2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cajal bodies and histone locus bodies in Drosophila and Xenopus. Nizami ZF, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21047905
    2. WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models. Di Giorgio ML, et al. Neurobiol Dis, 2017 Sep. PMID 28502804
    3. A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles. Tycowski KT, et al. Mol Cell, 2009 Apr 10. PMID 19285445, Free PMC Article
    4. Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body. Duronio RJ, et al. RNA Biol, 2017 Jun 3. PMID 28059623, Free PMC Article
    5. An inducible nuclear body in the Drosophila germinal vesicle. Singer AB, et al. Nucleus, 2011 Sep-Oct. PMID 21941118, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR79 as a central player in the localization and processing of nuclear RNPs.
      Title: A conserved WD40 protein binds the Cajal body localization signal of scaRNP particles.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables box C/D sno(s)RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Cajal body organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Cajal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Cajal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Cajal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    WD repeat domain 79
    Names
    CG9226-PB
    CG9226-PC
    WD repeat domain 79 homolog
    WDR79-PB
    WDR79-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6125879..6127775 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298736.1 → NP_001285665.1  WD repeat domain 79, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285665.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6NL34, Q960H9, Q9VMH1
      Conserved Domains (2) summary
      sd00039
      Location:294 → 332
      7WD40; WD40 repeat [structural motif]
      cl25539
      Location:273 → 490
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_135153.4 → NP_608997.3  WD repeat domain 79, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608997.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMH1
      Conserved Domains (3) summary
      COG2319
      Location:231 → 453
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:255 → 293
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:234 → 451
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NL34.1 Q6NL34

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools