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    Cht5 Chitinase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41687, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cht5provided by FlyBase
    Official Full Name
    Chitinase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038180
    Locus tag
    Dmel_CG9307
    See related
    AllianceGenome:FB:FBgn0038180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9307; Cht; cht5; DmCht5; DmCHT5; Dmel\CG9307
    Summary
    Enables chitin binding activity and chitinase activity. Involved in several processes, including chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube size, open tracheal system. Located in extracellular space. Is expressed in tracheal primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cht5 in Genome Data Viewer
    Location:
    87F13-87F13; 3-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13767549..13770732)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9593271..9596454)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ubiquitin conjugating enzyme 87F Neighboring gene kramer Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chitinase 10 controls chitin amounts and organization in the wing cuticle of Drosophila. Dong W, et al. Insect Sci, 2020 Dec. PMID 32129536
    2. Characterization of recombinant chitinase-like proteins of Drosophila melanogaster and Tribolium castaneum. Zhu Q, et al. Insect Biochem Mol Biol, 2008 Apr. PMID 18342251
    3. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. Camporeale G, et al. J Nutr, 2007 Apr. PMID 17374649, Free PMC Article
    4. Computational identification of novel chitinase-like proteins in the Drosophila melanogaster genome. Zhu Q, et al. Bioinformatics, 2004 Jan 22. PMID 14734306
    5. The biology of insect chitinases and their roles at chitinous cuticles. Rabadiya D, et al. Insect Biochem Mol Biol, 2024 Feb. PMID 38184175

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chitin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chitin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chitin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chitin-based cuticle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chitinase 5
    Names
    CG9307-PA
    Cht5-PA
    chitin-binding peritrophin-A
    NP_650314.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13767549..13770732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142057.3 → NP_650314.1  chitinase 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650314.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFR3
      Related
      FBpp0082294
      Conserved Domains (4) summary
      pfam05887
      Location:367 → 469
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      cd02872
      Location:29 → 397
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00636
      Location:28 → 379
      Glyco_18; Glyco_18 domain
      pfam01607
      Location:531 → 578
      CBM_14; Chitin binding Peritrophin-A domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFR3 Q9VFR3

    Gene LinkOut

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