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    MED17 Mediator complex subunit 17 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MED17provided by FlyBase
    Official Full Name
    Mediator complex subunit 17provided by FlyBase
    Primary source
    FLYBASE:FBgn0038578
    Locus tag
    Dmel_CG7957
    See related
    AllianceGenome:FB:FBgn0038578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7957; dMED17; Dmel\CG7957; dTrap80; dTRAP80; dTRAP80/SRB4; l(3)s2956; Med17; p70; Trap80; TRAP80
    Summary
    Enables DNA-binding transcription factor binding activity and transcription coregulator activity. Contributes to transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II and sex comb development. Located in nucleus and pericentric heterochromatin. Part of mediator complex. Is expressed in several structures, including antennal primordium; embryonic/larval midgut primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MED17 in Genome Data Viewer
    Location:
    90F6-90F6; 3-62 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18189072..18191265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14014794..14016987)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sequence-specific single-stranded DNA-binding protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain. Marr SK, et al. Biochim Biophys Acta, 2012 Aug. PMID 22484022, Free PMC Article
    2. A novel genetic system for analysis of co-activators for the N-terminal transactivation function domain of the human androgen receptor. Takeyama K, et al. Biosci Biotechnol Biochem, 2004 Jun. PMID 15215582
    3. Establishment of cell fate during early Drosophila embryogenesis requires transcriptional Mediator subunit dMED31. Bosveld F, et al. Dev Biol, 2008 Jan 15. PMID 18083158
    4. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
    5. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Boube M, et al. Cell, 2002 Jul 26. PMID 12150923

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dTRAP80 serves as a genuine activator-binding target responsible for a distinct group of activators.
      Title: Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription coregulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sex comb development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mediator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pericentric heterochromatin IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mediator complex subunit 17
    Names
    CG7957-PA
    MED17-PA
    mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18189072..18191265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142429.3 → NP_650686.1  mediator complex subunit 17 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650686.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VEC1
      Related
      FBpp0082980
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VEC1.1 Q9VEC1

    Gene LinkOut

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