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    alpha-Man-IIa alpha-Mannosidase class II a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    alpha-Man-IIaprovided by FlyBase
    Official Full Name
    alpha-Mannosidase class II aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011740
    Locus tag
    Dmel_CG18802
    See related
    AllianceGenome:FB:FBgn0011740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    agr;-Man-II; alpha-Man-II; alpha-Man-IIA; alpha-Man-IIalpha; CG18474; CG18802; CG8139; dGMII; dGMIIb; DM-GII.1; Dmel\CG18802; GmII; GMII; Man; MAN-2; Man-II
    Summary
    Enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity. Involved in N-glycan processing; encapsulation of foreign target; and rhodopsin biosynthetic process. Located in Golgi membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See alpha-Man-IIa in Genome Data Viewer
    Location:
    85D15-85D16; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9412548..9417264)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5238270..5242986)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beta-Tubulin at 85D Neighboring gene TWIK-related acid-sensitive K[+] channel 7 Neighboring gene pasilla Neighboring gene Glutathione S transferase Z1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Golgi α-mannosidase: opposing structures of Drosophila melanogaster and novel human model using molecular dynamics simulations and docking at different pHs. Drogalin A, et al. J Biomol Struct Dyn, 2024 Mar. PMID 37158092
    2. Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site. Shah N, et al. Proc Natl Acad Sci U S A, 2008 Jul 15. PMID 18599462, Free PMC Article
    3. The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A. Kuntz DA, et al. Chembiochem, 2009 Jan 26. PMID 19101978, Free PMC Article
    4. A long-wavelength fluorescent substrate for continuous fluorometric determination of alpha-mannosidase activity: resorufin alpha-D-mannopyranoside. Coleman DJ, et al. Anal Biochem, 2010 Apr 1. PMID 20026005, Free PMC Article
    5. Structural investigation of the binding of 5-substituted swainsonine analogues to Golgi alpha-mannosidase II. Kuntz DA, et al. Chembiochem, 2010 Mar 22. PMID 20209559

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data show that the Drosophila metallophosphoesterase-dephosphorylated alpha-Man-II is required for the removal of the Rh1 oligosaccharide chain.
      Title: A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin.
    2. high-resolution crystal structure of a nucleophile mutant of Drosophila melanogaster GMII bound to its natural oligosaccharide substrate and an oligosaccharide precursor as well as the structure of the unliganded mutant.
      Title: Golgi alpha-mannosidase II cleaves two sugars sequentially in the same catalytic site.
    3. Drosophila melanogaster Golgi alpha-mannosidase II mechanism seen through the structural analysis of covalent reaction intermediates
      Title: Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in encapsulation of foreign target IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rhodopsin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-Mannosidase class II a
    Names
    CG18802-PA
    CG18802-PB
    alpha mannosidase II
    alpha-Man-IIa-PA
    alpha-Man-IIa-PB
    alpha-mannosidase 2
    alpha-mannosidase II
    alpha-mannosidase-II
    chain A, golgi Alpha-Mannosidase Ii
    golgi Man II
    golgi alpha-mannosidase
    golgi alpha-mannosidase II
    golgi mannosidase II
    mannosidase II
    NP_001262413.1
    NP_524291.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9412548..9417264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275484.1 → NP_001262413.1  alpha-Mannosidase class II a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFG0
      Conserved Domains (3) summary
      cd10809
      Location:144 → 483
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:478 → 554
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:744 → 1103
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain

    2. NM_079567.3 → NP_524291.2  alpha-Mannosidase class II a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524291.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24451, Q9TYG5, Q9VHD8, Q9VHD9
      Related
      FBpp0081509
      Conserved Domains (3) summary
      cd10809
      Location:143 → 482
      GH38N_AMII_GMII_SfManIII_like; N-terminal catalytic domain of Golgi alpha-mannosidase II, Spodoptera frugiperda Sf9 alpha-mannosidase III, and similar proteins; glycoside hydrolase family 38 (GH38)
      smart00872
      Location:477 → 553
      Alpha-mann_mid; Alpha mannosidase, middle domain
      pfam07748
      Location:743 → 1102
      Glyco_hydro_38C; Glycosyl hydrolases family 38 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFG0 A0A0B4KFG0
    Q24451.2 Q24451

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