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    Bdp1 B double prime 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bdp1provided by FlyBase
    Official Full Name
    B double prime 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0032512
    Locus tag
    Dmel_CG9305
    See related
    AllianceGenome:FB:FBgn0032512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9305; Dmel\CG9305
    Summary
    Enables RNA polymerase III type 3 promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase III preinitiation complex assembly. Part of transcription factor TFIIIB complex. Is expressed in several structures, including anterior endoderm; dorsal pharyngeal muscle primordium; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 112. Orthologous to human BDP1 (B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bdp1 in Genome Data Viewer
    Location:
    34B8-34B8; 2-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13371427..13373890, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13371427..13373890, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Two A-associated protein of 42kDa Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B22 subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking. Kang JJ, et al. FEBS Lett, 2016 May. PMID 27112515
    2. Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster. Kim MK, et al. Mol Cell Biol, 2020 May 28. PMID 32253345, Free PMC Article
    3. Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex. Verma N, et al. FEBS Lett, 2018 Jul. PMID 29932462
    4. Differential utilization of TATA box-binding protein (TBP) and TBP-related factor 1 (TRF1) at different classes of RNA polymerase III promoters. Verma N, et al. J Biol Chem, 2013 Sep 20. PMID 23955442, Free PMC Article
    5. A Genetic Mosaic Screen Reveals Ecdysone-Responsive Genes Regulating Drosophila Oogenesis. Ables ET, et al. G3 (Bethesda), 2016 Aug 9. PMID 27226164, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster.
      Title: Assembly of SNAPc, Bdp1, and TBP on the U6 snRNA Gene Promoter in Drosophila melanogaster.
    2. Bdp1 recruitment requires that DmSNAPc be bound to a U6 PSE rather than a U1 PSE. This is consistent with the concept that DmSNAPc adopts different conformations on U6 and U1 PSEs, which lead to the subsequent recruitment of distinct general transcription factors and RNA polymerases for U6 and U1 gene transcription.
      Title: Bdp1 interacts with SNAPc bound to a U6, but not U1, snRNA gene promoter element to establish a stable protein-DNA complex.
    3. Results indicate that a portion of Brf1 is sandwiched between Bdp1 and TBP upstream of the U6 TATA box. Furthermore, Bdp1 traverses the DNA under the N-terminal stirrup of TBP to interact with the DNA (and very likely Brf1) downstream of the TATA sequence.
      Title: TFIIIB subunit locations on U6 gene promoter DNA mapped by site-specific protein-DNA photo-cross-linking.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA polymerase III type 3 promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables TFIIIC-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase III preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of transcription factor TFIIIB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIB complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B double prime 1
    Names
    Bdp1-PA
    Bdp1-PB
    CG9305-PA
    CG9305-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13371427..13373890 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298961.1 → NP_001285890.1  B double prime 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285890.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNW3, X2J875
      Conserved Domains (2) summary
      smart00717
      Location:350 → 395
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam15963
      Location:345 → 419
      Myb_DNA-bind_7; Myb DNA-binding like

    2. NM_135799.3 → NP_609643.2  B double prime 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609643.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NNW3, Q9VJZ3
      Related
      FBpp0080050
      Conserved Domains (2) summary
      smart00717
      Location:350 → 395
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam15963
      Location:345 → 419
      Myb_DNA-bind_7; Myb DNA-binding like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VJZ3 Q9VJZ3
    X2J875 X2J875

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