U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TTLL5 Tubulin tyrosine ligase-like 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43015, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    TTLL5provided by FlyBase
    Official Full Name
    Tubulin tyrosine ligase-like 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0051108
    Locus tag
    Dmel_CG31108
    See related
    AllianceGenome:FB:FBgn0051108
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10057; CG31108; DmCG31108; Dmel\CG31108; DmTTLL5
    Summary
    Enables tubulin-glutamic acid ligase activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in ciliary basal body. Is expressed in several structures, including central brain primordium; embryonic central brain neurons; embryonic/larval midgut primordium; ganglia; and sensory nervous system primordium. Human ortholog(s) of this gene implicated in cone-rod dystrophy 19. Orthologous to human TTLL5 (tubulin tyrosine ligase like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TTLL5 in Genome Data Viewer
    Location:
    96C1-96C1; 3-87 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25112867..25122920, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20938589..20948642, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 16 Neighboring gene uncharacterized protein Neighboring gene vig2 Neighboring gene Molybdenum cofactor synthesis 2B Neighboring gene Molybdenum cofactor synthesis 2A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System. Devambez I, et al. Sci Rep, 2017 Nov 24. PMID 29176602, Free PMC Article
    2. Differential modification of the C-terminal tails of different α-tubulins and their importance for microtubule function in vivo. Bao M, et al. Elife, 2023 Jun 22. PMID 37345829, Free PMC Article
    3. Predicting gene regulatory interactions based on spatial gene expression data and deep learning. Yang Y, et al. PLoS Comput Biol, 2019 Sep. PMID 31527870, Free PMC Article
    4. Causal and Candidate Gene Variants in a Large Cohort of Women With Primary Ovarian Insufficiency. Gorsi B, et al. J Clin Endocrinol Metab, 2022 Feb 17. PMID 34718612, Free PMC Article
    5. Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Janke C, et al. Science, 2005 Jun 17. PMID 15890843

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TTLL5 was identified as a major tubulin glutamylase in Drosophila neurons.
      Title: Identification of DmTTLL5 as a Major Tubulin Glutamylase in the Drosophila Nervous System.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin-glutamic acid ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    tubulin tyrosine ligase-like 5
    Names
    CG31108-PA
    CG31108-PB
    TTLL5-PA
    TTLL5-PB
    NP_001287520.1
    NP_733081.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25112867..25122920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170202.3 → NP_733081.1  tubulin tyrosine ligase-like 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBX5
      Related
      FBpp0084177
      Conserved Domains (1) summary
      pfam03133
      Location:266 → 549
      TTL; Tubulin-tyrosine ligase family

    2. NM_001300591.1 → NP_001287520.1  tubulin tyrosine ligase-like 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287520.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBX5
      Conserved Domains (1) summary
      pfam03133
      Location:266 → 549
      TTL; Tubulin-tyrosine ligase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBX5 Q9VBX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools