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    Cdc2rk Cdc2-related kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36051, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdc2rkprovided by FlyBase
    Official Full Name
    Cdc2-related kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013435
    Locus tag
    Dmel_CG1362
    See related
    AllianceGenome:FB:FBgn0013435
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cdc2rk; CG1362; Dcdrk; Dmel\CG1362
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human CDK10 (cyclin dependent kinase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Cdc2rk in Genome Data Viewer
    Location:
    46E1-46E1; 2-62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10067217..10068702, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5954722..5956207, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene magu Neighboring gene Defensin Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class N Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene snoRNA:Orphan H/ACA box 7 Neighboring gene eiger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel Drosophila gene encoding a Cdc2-related protein kinase. Sugaya R, et al. J Biochem, 1994 Jan. PMID 8188624
    2. Phosphorylation of Drosophila CENP-A on serine 20 regulates protein turn-over and centromere-specific loading. Huang A, et al. Nucleic Acids Res, 2019 Nov 18. PMID 31535131, Free PMC Article
    3. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. Liu J, et al. Mol Biol Evol, 2000 Jul. PMID 10889219
    4. Multiplexed conditional genome editing with Cas12a in Drosophila. Port F, et al. Proc Natl Acad Sci U S A, 2020 Sep 15. PMID 32843348, Free PMC Article
    5. Evolution of protein kinase signaling from yeast to man. Manning G, et al. Trends Biochem Sci, 2002 Oct. PMID 12368087

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Cdc2-related kinase
    Names
    CG1362-PA
    Cdc2rk-PA
    cdc2-related-kinase
    NP_523674.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10067217..10068702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078950.4 → NP_523674.1  Cdc2-related kinase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523674.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z840, C6SUX7
      Related
      FBpp0087515
      Conserved Domains (2) summary
      cd07845
      Location:45 → 353
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
      smart00220
      Location:53 → 337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z840 A1Z840
    Q24294 Q24294
    Q8IGS3 Q8IGS3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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