Cbp20 cap binding protein 20 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cbp20provided by FlyBase
Official Full Name: cap binding protein 20provided by FlyBase
Primary source: FLYBASE:FBgn0022943
Locus tag: Dmel_CG12357
See related: AllianceGenome:FB:FBgn0022943
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cbp20; CBP20; CG12357; Dmel\CG12357
Summary: Predicted to enable RNA cap binding activity and mRNA binding activity. Involved in primary miRNA processing; regulatory ncRNA-mediated post-transcriptional gene silencing; and siRNA processing. Located in nucleus and presynaptic cytosol. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Used to study chromosome 3q29 microdeletion syndrome. Orthologous to several human genes including NCBP2 (nuclear cap binding protein subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (18164661..18165439)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (13990383..13991161)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA cap binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA cis splicing, via spliceosome	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear cap binding complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear cap binding complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed
located_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

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