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    hfw halfway [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hfwprovided by FlyBase
    Official Full Name
    halfwayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001189
    Locus tag
    Dmel_CG3095
    See related
    AllianceGenome:FB:FBgn0001189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3095; CT10406; Dmel\CG3095; EG:171E4.2; l(1)2Bf; l(1)nfw; swi; SWI
    Summary
    Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Involved in intracellular signal transduction; pupariation; and response to ecdysone. Predicted to be part of voltage-gated potassium channel complex. Is expressed in several structures, including embryonic/larval midgut primordium; gut section; larval muscle system; mesoderm; and visceral muscle primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See hfw in Genome Data Viewer
    Location:
    2B5-2B6; 1-0.2 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1669570..1673608)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1563603..1567641)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Mucin related 2B Neighboring gene broad Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene deep orange Neighboring gene uncharacterized protein Neighboring gene b6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Testing odor response stereotypy in the Drosophila mushroom body. Murthy M, et al. Neuron, 2008 Sep 25. PMID 18817738, Free PMC Article
    2. [Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin]. Mazina MIu, et al. Tsitologiia, 2013. PMID 23875451
    3. Linking histone acetylation to transcriptional regulation. Mizzen CA, et al. Cell Mol Life Sci, 1998 Jan. PMID 9487383, Free PMC Article
    4. Localization of genes ecs, dor and swi in eight Drosophila species. Kokoza EB, et al. Genetica, 1992. PMID 1490629
    5. [Localization of ecs, dor and swl genes in eight Drosophila species]. Kokoza EB, et al. Genetika, 1991 Dec. PMID 1802794

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Insulator protein Su(Hw) recruits histone acetyltransferase complex SAGA and chromatin remodeler dSWI/SNF to Su(Hw)-dependent insulators and creates platform for origin recognition complex binding.
      Title: [Ability of Su(Hw) to create a platform for ORC binding does not depend on the type of surrounding chromatin].
    2. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs.
      Title: SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster.
    3. Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
      Title: Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pupariation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to ecdysone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    halfway
    Names
    CG3095-PA
    CG3095-PB
    hfw-PA
    hfw-PB
    singed wings
    singed-wings

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1669570..1673608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272206.1 → NP_001259135.1  halfway, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46061, Q8SZE5, Q9W568
      UniProtKB/TrEMBL
      B6IDK2, F0JAN4
      Conserved Domains (2) summary
      sd00031
      Location:237 → 259
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:235 → 294
      LRR_8; Leucine rich repeat

    2. NM_130577.4 → NP_569933.2  halfway, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569933.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O46061, Q8SZE5, Q9W568
      UniProtKB/TrEMBL
      B6IDK2, F0JAN4
      Related
      FBpp0070260
      Conserved Domains (2) summary
      sd00031
      Location:237 → 259
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:235 → 294
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6IDK2 B6IDK2
    Q9W568.3 Q9W568

    Gene LinkOut

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