Vha13 Vacuolar H[+] ATPase 13kD subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vha13provided by FlyBase
Official Full Name: Vacuolar H[+] ATPase 13kD subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0283536
Locus tag: Dmel_CG6213
See related: AllianceGenome:FB:FBgn0283536
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ATP6V1G; BcDNA:AT14009; CG6213; chr3R:15469897..15470039; cnj; conjoined; Dmel\CG6213; l(3)05113; vha13; Vha13-1; VhaG
Summary: Predicted to enable ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Involved in terminal branching, open tracheal system. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in adult head. Orthologous to several human genes including ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19643018..19644386, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15468740..15470108, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate.
Title: Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IBA Inferred from Biological aspect of Ancestor more info
contributes_to proton-transporting ATPase activity, rotational mechanism	IC Inferred by Curator more info	PubMed
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in liquid clearance, open tracheal system	HMP more info	PubMed
involved_in proton transmembrane transport	IC Inferred by Curator more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in synaptic vesicle lumen acidification	IBA Inferred from Biological aspect of Ancestor more info
involved_in terminal branching, open tracheal system	HMP more info	PubMed
involved_in terminal branching, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of plasma membrane proton-transporting V-type ATPase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of vacuolar proton-transporting V-type ATPase complex	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase, V1 domain	IBA Inferred from Biological aspect of Ancestor more info

Names: CG6213-PA; CG6213-PB; Vha13-PA; Vha13-PB; conjoined; vacuolar H[+] ATPase G-subunit

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The following sections contain reference sequences that belong to a specific genome build. Explain