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    Vsx2 Visual system homeobox 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vsx2provided by FlyBase
    Official Full Name
    Visual system homeobox 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0263512
    Locus tag
    Dmel_CG33980
    See related
    AllianceGenome:FB:FBgn0263512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15781; CG15782; CG15783; CG33980; Chx2; dChx2; DChx2; Dmel\CG33980; dVsx2; Vsx; vsx2
    Summary
    Predicted to enable DNA-binding transcription factor activity and sequence-specific double-stranded DNA binding activity. Involved in insect visual primordium development. Predicted to be active in nucleus. Is expressed in cell body rind of adult medulla and organism. Human ortholog(s) of this gene implicated in blindness and isolated microphthalmia 2. Orthologous to human VSX2 (visual system homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Vsx2 in Genome Data Viewer
    Location:
    5A3-5A5; 1-12 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5528927..5560183, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5422960..5454216, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45518 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Visual system homeobox 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordinated control of neuronal differentiation and wiring by sustained transcription factors. Özel MN, et al. Science, 2022 Dec 23. PMID 36480601, Free PMC Article
    2. Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. Erclik T, et al. Curr Biol, 2008 Sep 9. PMID 18723351
    3. Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites. Landgraf M, et al. Dev Biol, 2003 Aug 1. PMID 12885565
    4. Pax3/7 genes reveal conservation and divergence in the arthropod segmentation hierarchy. Davis GK, et al. Dev Biol, 2005 Sep 1. PMID 16083872
    5. Spatial patterning controls neuron numbers in the Drosophila visual system. Malin JA, et al. Dev Cell, 2024 May 6. PMID 38531357,

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in insect visual primordium development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    visual system homeobox 2
    Names
    CG33980-PA
    CG33980-PB
    Chx2
    Vsx2-PA
    Vsx2-PB
    visual system homeobox 2 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5528927..5560183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001038743.1 → NP_001033832.1  visual system homeobox 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033832.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6W6, Q9W4B3
      Conserved Domains (2) summary
      pfam00046
      Location:233 → 286
      Homeobox; Homeobox domain
      pfam03826
      Location:551 → 565
      OAR; OAR domain

    2. NM_001297968.1 → NP_001284897.1  visual system homeobox 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDS9
      Conserved Domains (2) summary
      pfam00046
      Location:233 → 286
      Homeobox; Homeobox domain
      pfam03826
      Location:556 → 570
      OAR; OAR domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W4B3 Q9W4B3
    X2JDS9 X2JDS9

    Gene LinkOut

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