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    lin-52 lin-52 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lin-52provided by FlyBase
    Official Full Name
    lin-52provided by FlyBase
    Primary source
    FLYBASE:FBgn0029800
    Locus tag
    Dmel_CG15929
    See related
    AllianceGenome:FB:FBgn0029800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15929; dlin-52; dLin-52; dLIN-52; dlin52; dLin52; Dmel\CG15929; Lin-52; Lin52; LIN52
    Summary
    Involved in compound eye development; negative regulation of execution phase of apoptosis; and negative regulation of transcription by RNA polymerase II. Located in euchromatin and polytene chromosome. Part of DRM complex and Myb complex. Is active in nucleus. Is expressed in several structures, including egg chamber; embryonic/larval fat body; embryonic/larval optic lobe; ganglia; and imaginal disc. Orthologous to human LIN52 (lin-52 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See lin-52 in Genome Data Viewer
    Location:
    5B6-5B7; 1-13 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5753390..5754958, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5647423..5648991, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Integrator 6 Neighboring gene Regulator of telomere elongation helicase 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45528 Neighboring gene uncharacterized protein Neighboring gene MAP kinase activated protein-kinase-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic pattern of expression of dlin52, a member of the Myb/MuvB complex, during Drosophila development. Bhaskar PK, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22178095
    2. A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Vorster PJ, et al. Biol Open, 2020 May 7. PMID 32295830, Free PMC Article
    3. DREAM a little dREAM of DRM: Model organisms and conservation of DREAM-like complexes: Model organisms uncover the mechanisms of DREAM-mediated transcription regulation. Hoareau M, et al. Bioessays, 2024 Feb. PMID 38059789
    4. dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid. Bhaskar PK, et al. Biochim Biophys Acta, 2014 Sep. PMID 24863159
    5. Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Lewis PW, et al. Mol Cell Biol, 2012 Aug. PMID 22688510, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. conclude that dLin52 functions as a co-factor and modulates activity of members of dMyb/dREAM complex at hid promoter, thus regulating apoptosis by repressing this pro-apoptotic gene in the developing Drosophila eye
      Title: dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid.
    2. the Lin-52 and Myb proteins counteract the repressive activities of the other members of the MMB/dREAM complex at specific genomic loci in a developmentally controlled manner
      Title: Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.
    3. dlin52 is expressed in the larval optic lobe, as well as in the developing neurons of ventral ganglion, indicating that this gene has an important role to play in cell cycle regulation and neuronal development.
      Title: Dynamic pattern of expression of dlin52, a member of the Myb/MuvB complex, during Drosophila development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of execution phase of apoptosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DRM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lin-52
    Names
    CG15929-PA
    CG15929-PB
    lin-52-PA
    lin-52-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5753390..5754958 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297979.1 → NP_001284908.1  lin-52, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284908.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6K9, Q9W482
      Conserved Domains (1) summary
      pfam10044
      Location:55 → 147
      LIN52; Retinal tissue protein

    2. NM_132028.3 → NP_572256.1  lin-52, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V6K9, Q9W482
      Related
      FBpp0070805
      Conserved Domains (1) summary
      pfam10044
      Location:55 → 147
      LIN52; Retinal tissue protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W482 Q9W482

    Gene LinkOut

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