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    Tmf TATA element modulatory factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmfprovided by FlyBase
    Official Full Name
    TATA element modulatory factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029912
    Locus tag
    Dmel_CG4557
    See related
    AllianceGenome:FB:FBgn0029912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAF46211; CG4557; Dmel\CG4557; TMF
    Summary
    Enables cargo receptor activity. Involved in intra-Golgi vesicle-mediated transport and vesicle tethering to Golgi. Is active in trans-Golgi network membrane. Orthologous to human TMF1 (TATA element modulatory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmf in Genome Data Viewer
    Location:
    6D5-6D6; 1-18 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6844341..6847847)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6738374..6741880)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene no-on-and-no-off transient C Neighboring gene muscarinic Acetylcholine Receptor, C-type Neighboring gene uncharacterized protein Neighboring gene Chitinase 11 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus. Park SY, et al. Curr Biol, 2022 Nov 7. PMID 36103876, Free PMC Article
    2. TMF is a golgin that binds Rab6 and influences Golgi morphology. Fridmann-Sirkis Y, et al. BMC Cell Biol, 2004 May 5. PMID 15128430, Free PMC Article
    3. The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. Long AA, et al. J Cell Sci, 2010 Oct 1. PMID 20826458, Free PMC Article
    4. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article
    5. Protein interactions on telomeric retrotransposons in Drosophila. Takács S, et al. Int J Biol Sci, 2012. PMID 22949888, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cargo receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle tethering to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TATA element modulatory factor
    Names
    CG4557-PA
    Tmf-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6844341..6847847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132132.3 → NP_572360.1  TATA element modulatory factor [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572360.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3V2
      Related
      FBpp0070954
      Conserved Domains (3) summary
      pfam07798
      Location:420 → 527
      DUF1640; Protein of unknown function (DUF1640)
      pfam12325
      Location:813 → 918
      TMF_TATA_bd; TATA element modulatory factor 1 TATA binding
      pfam12329
      Location:405 → 472
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3V2 Q9W3V2

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