hec hector [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hecprovided by FlyBase
Official Full Name: hectorprovided by FlyBase
Primary source: FLYBASE:FBgn0030437
Locus tag: Dmel_CG4395
See related: AllianceGenome:FB:FBgn0030437
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0170980.1; anon-WO0170980.2; CG4395; Dmel\CG4395; Hec
Summary: Predicted to enable calcitonin receptor activity and neuropeptide receptor activity. Involved in male courtship behavior. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; adult ellipsoid body R-neuron; adult head; synaptic neuropil domain; and synaptic neuropil subdomain. Human ortholog(s) of this gene implicated in hereditary lymphedema and osteoporosis. Orthologous to human CALCR (calcitonin receptor) and CALCRL (calcitonin receptor like receptor). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (12950436..12957462, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (12844469..12851495, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcitonin receptor activity	IEA Inferred from Electronic Annotation more info
enables calcitonin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

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The following sections contain reference sequences that belong to a specific genome build. Explain