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    CG9784 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32629, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG9784provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030761
    Locus tag
    Dmel_CG9784
    See related
    AllianceGenome:FB:FBgn0030761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9784; IPP; lincRNA.S9473
    Summary
    Predicted to enable inositol trisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in neuron projection; plasma membrane; and ruffle. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5J (inositol polyphosphate-5-phosphatase J) and INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG9784 in Genome Data Viewer
    Location:
    14F1-14F2; 1-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16595136..16599215, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16489169..16493248, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Structural maintenance of chromosomes 3 Neighboring gene Ubiquitin conjugating enzyme 7 Neighboring gene Nucleoporin 153kD Neighboring gene mir-4965 stem loop Neighboring gene mushroom bodies tiny Neighboring gene stable intronic sequence RNA 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
    2. A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. Parsons LM, et al. G3 (Bethesda), 2017 Aug 7. PMID 28611255, Free PMC Article
    3. Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. Bulat V, et al. J Cell Biol, 2014 Jan 6. PMID 24395637, Free PMC Article
    4. Hypoxia controls plasma membrane targeting of polarity proteins by dynamic turnover of PI4P and PI(4,5)P2. Lu J, et al. Elife, 2022 Jun 9. PMID 35678383, Free PMC Article
    5. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables inositol trisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9784-PA
    CG9784-PB
    CG9784-PC
    NP_001259623.1
    NP_001259624.1
    NP_573135.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16595136..16599215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132907.3 → NP_573135.1  uncharacterized protein Dmel_CG9784, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXE7
      Related
      FBpp0074064
      Conserved Domains (1) summary
      cd09094
      Location:31 → 341
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

    2. NM_001272695.2 → NP_001259624.1  uncharacterized protein Dmel_CG9784, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259624.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXE7
      Conserved Domains (1) summary
      cd09094
      Location:31 → 341
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins

    3. NM_001272694.2 → NP_001259623.1  uncharacterized protein Dmel_CG9784, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHS8
      Conserved Domains (1) summary
      cd09094
      Location:31 → 341
      INPP5c_INPP5J-like; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of inositol polyphosphate 5-phosphatase J and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHS8 M9PHS8
    Q9VXE7 Q9VXE7

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